Renal Function in Children with Cyanotic Congenital Heart Disease: Pre- and Post-Cardiac Surgery Evaluation

Mitra  Basiratnia; Hamid  Amoozgar; Fatemeh Ghasemi

IJ Pediatrics

The Scientific Journal of Growth & Development Research Center

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Renal Function in Children with Cyanotic Congenital Heart Disease: Pre- and Post-Cardiac Surgery Evaluation

Author(s):

Mitra Basiratnia^1,*,

Hamid Amoozgar²,

Fatemeh Ghasemi³

IJ Pediatrics:Vol. 24, issue 1; 81-86

Published online:Jan 25, 2014

Article type:Research Article

Received:Jul 06, 2013

Accepted:Jan 11, 2014

How to Cite:Mitra BasiratniaHamid AmoozgarFatemeh GhasemiRenal Function in Children with Cyanotic Congenital Heart Disease: Pre- and Post-Cardiac Surgery Evaluation.Iran J Pediatr.24(1):81-86.

Abstract

Objective: Cyanotic congenital heart diseases (CCHDs) are a series of cardiac anomalies that have long been recognized as a potential cause of nephropathy. There have been few reports on renal impairment in patients with CCHD before and after corrective cardiac surgery. The aim of this study was to evaluate the prevalence of renal dysfunction before and after cardiac surgery and the impact of some risk factors on final renal outcome. Methods: Thirty children with CCHD who had done corrective cardiac surgery in the previous 6 months were enrolled in this study. All data prior to surgery were collected from the charts. Post-operation data including blood and spot urine samples were taken simultaneously for CBC, Cr, and uric acid and 24 hour urine was collected for microalbumin and Cr during the follow up visits. Pre- and post-operation parameters were compared to study the impact of cardiac surgery on renal function. Findings: Pre- and post-operative GFRs were not significantly different. Final GFR was significantly and inversely associated with pre- and post-operation age (P=0.008 r=-0.48, P=0.03 r=-0.38). Three (10%) patients had microalbuminuria. The prevalence of microalbuminuria in children older than 10 years was 30%. There was no link between microalbuminuria and age, GFR, and hematocrit (P=0.1, P=0.3, P=0.3, respectively). Patients with preoperation hematocrit >45 had a significantly lower final GFR compared to children with HCT

Keywords

Congenital Heart Disease

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