Does Stress and Anxiety Contribute to COVID-19?


avatar Majid Taati Moghadam ORCID 1 , avatar Sajad Babakhani 2 , avatar Sajad Rajabi ORCID 3 , avatar Fatemeh Bagheri Baravati 4 , avatar Mohammadali Raeisi 5 , avatar Amin Sadeghi Dousari 6 , *

Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Department of Microbiology, North Tehran Branch, Islamic Azad University, Tehran, Iran
International Campus, Iran University of Medical Sciences, Tehran, Iran
Noncommunicable Diseases Research Center, Bam University of Medical Sciences , Bam, Iran
Department of Neurology, Pastor Hospital, Bam University of Medical Sciences, Bam, Iran
Jiroft University of Medical Sciences, Jiroft, Iran

how to cite: Taati Moghadam M, Babakhani S, Rajabi S, Bagheri Baravati F, Raeisi M, et al. Does Stress and Anxiety Contribute to COVID-19?. Iran J Psychiatry Behav Sci. 2021;15(1):e106041. doi: 10.5812/ijpbs.106041.

Dear editor,

Stressful situations often cause a wide range of emotions and behaviors, such as anxiety, disturbed sleep, sadness, irritability, anger, and violence. There is evidence indicating that stress can increase the risk of several health conditions, including infectious diseases (viral, bacterial, and parasitic), childhood cancer, etc. (1-5). It also negatively affects the immune system. So that several studies reported that social stressors are associated with increased inflammatory cytokines, which highlights the central nervous system (CNS) signal to induce behavioral, neurological changes with psychiatric symptoms. Therefore, it can be argued that inflammatory cytokines are a major factor in the pathogenesis of stress, anxiety, depression, and other mental disorders (6, 7). Thus, the proliferation of T cells, which are responsible for cellular immunity and the most important arm of the immune system to fight viruses, is reduced in anxious patients. Moreover, it is well-proved that stress is associated with delayed response to the vaccine as well as exacerbated viral and bacterial pathogens. Stress hormones also disrupt the trafficking of neutrophils, macrophages, antigen-containing cells, natural killer (NK) cells, T and B lymphocytes, and produce the necessary cytokines to produce immune responses (8). As a result of the COVID-19 pandemic, which has infected nearly 6.5 million cases and claimed thousands of lives, people are faced with stressful conditions (9). Many studies have shown that one of the best ways to deal with COVID-19 is to strengthen the immune system; Nevertheless, stress, anxiety, and fear, which have increased since the onset of the pandemic, weaken the immune system, which increases susceptibility to developing various diseases (10).

Increased stress, anxiety, and fear can be attributed to factors such as the high mortality rate of COVID-19, the shortage of medical staff, improper treatments, insufficient medical equipment, and scarcity of food, as well as the ambiguous future of the disease (11). In this critical situation, psychologists play an important role because they take care of people’s mental health, so the necessary measures should be provided in an excellent way to reduce people’s stress. Therefore, considering that stress and anxiety can weaken the immune system, especially in the elderly, it is recommended that patients with COVID-19 be monitored by psychologists to manage the predisposing factors. During the COVID-19 pandemic, families of patients who suffer from mental fatigue also require psychological support. Providing training on managing psychological problems through national broadcasting also would be useful.


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