Serum Lipid Concentrations in Iranian Veterans with Combat-Related Chronic Posttraumatic Stress Disorder

Habibolah Khazaie; Masoud Tahmasian; Moslem Khoshbakh; Azita Chehri; Amir Ali Sepehry

IJ Psychiatry and Behavioral Sciences

IJPBS is the Official Journal of Mazandaran University of Medical Sciences

Current Issue All Issues In Press Search Accepted Manuscripts

Journal Information Editors & Boards Indexing and Listing Sources Journal Metrics Publication Ethics and Publication Malpractice Statement Reviewer and AE Registration Form Support Contact Us Open Peer Review (OPR)

APC

Authors Guide Submit Manuscript

Serum Lipid Concentrations in Iranian Veterans with Combat-Related Chronic Posttraumatic Stress Disorder

Author(s):

Habibolah Khazaie¹,

Masoud Tahmasian^1,*,

Moslem Khoshbakh¹,

Azita Chehri¹,

Amir Ali Sepehry²

1Sleep Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Fernand -Seguin research center, Louis -H Lafontaine hospital, Faculty of Medicine, Montreal university, Department of Psychiatry, Montreal, Canada

IJ Psychiatry and Behavioral Sciences:Vol. 1, issue 1; 22-6

Published online:Jan 30, 2007

Article type:Research Article

Received:Dec 05, 2006

Accepted:Jan 01, 2007

How to Cite:Khazaie H, Tahmasian M, Khoshbakh M, Chehri A, Sepehry A A. Serum Lipid Concentrations in Iranian Veterans with Combat-Related Chronic Posttraumatic Stress Disorder.Iran J Psychiatry Behav Sci.2007;1(1):22-6.

Abstract

Objective: Several studies demonstrated changes in serum lipid concentrations in chronic post traumatic stress disorder (cPTSD) patients. The purpose of this study was to assess serum lipid concentrations in soldiers with cPTSD and compare it with chronic major depressive disorder (cMDD) patients.

Methods: We measured serum lipid concentrations in patients with cPTSD (n=40) and cMDD (n=40) and compared the results. The patients were all male (30-48 years old) and had an illness history of more than 2 years prior to conducting the study. The groups were matched regarding their body mass index (BMI) and duration of symptoms. Laboratory investigations and psychiatric evaluations were carried-out 5 days after admission. Serum lipid concentrations were measured by enzyme assay (EA).

Results: cPTSD group showed significantly greater mean cholesterol concentrations (227.3 ± 69.7 mg/dL) than the cMDD group (190.7 ± 35.4 mg/dL) (p=0.004). Mean high density lipoprotein cholesterol (HDL-C) concentrations for cPTSD patients (66.6 ± 17.6 mg/dl) was significantly lower than HDL-C level in cMDD patients (76.5 ± 19.7 mg/dL) (p= 0.02). In contrast, mean low density lipoprotein cholesterol (LDL-C) concentrations for cPTSD patients (118.9 ± 60.1 mg/dL) was significantly higher than LDL-C level in cMDD patients (76.5 ± 25.2 mg/dL) (p= 0.000). Although similar differences was noticed on triglycerides concentration (cPTSD; 220.2 ± 79.0 and cMDD; 201.0 ± 61.8), it was statistically non-significant (p= 0.23).

Conclusion: Our findings suggest that cPTSD patients are at high risk of developing arteriosclerosis and vascular incident secondary to low levels of HDL-C and high levels of LDL-C.

Keywords

Fulltext

Full text is available in the PDF.

References

1.
References are available in the PDF.

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Metrics

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Habibolah Khazaie:[PubMed][Scholar]
Masoud Tahmasian:[PubMed][Scholar]
Moslem Khoshbakh:[PubMed][Scholar]
Azita Chehri:[PubMed][Scholar]
Amir Ali Sepehry:[PubMed][Scholar]