The Pattern of Adherence in Patients with Bipolar I Disorder; an Eight Weeks Study

Ali Sharifi; Amir Shabani; Masoud Ahmadzad-Asl

IJ Psychiatry and Behavioral Sciences

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The Pattern of Adherence in Patients with Bipolar I Disorder; an Eight Weeks Study

Author(s):

Ali Sharifi¹,

Amir Shabani¹,

Masoud Ahmadzad-Asl^2,*

1Tehran Psychiatric Institute, Mental Health Research Centre, Iran University of Medical Sciences and Health Services, Tehran, Iran

2Tehran Psychiatric Institute, Mansouri St, Niyayesh St, Sattarkhan Ave, Tehran, Iran

IJ Psychiatry and Behavioral Sciences:Vol. 3, issue 2; 39-43

Published online:Dec 31, 2009

Article type:Research Article

Received:Jul 05, 2009

Accepted:Sep 29, 2009

How to Cite:Ali SharifiAmir Shabani Masoud Ahmadzad-AslThe Pattern of Adherence in Patients with Bipolar I Disorder; an Eight Weeks Study.Iran J Psychiatry Behav Sci.3(2):39-43.

Abstract

Objectives: Non-adherence limits the effectiveness of medications among patients with bipolar disorder. Many studies have investigated the predicting factors of non-adherence. This paper aims to present the pattern of adherence in patients with bipolar I disorder (BID).

Methods: Seventy six patients with BID enrolled in a prospective study. The Medication Possession Ratio (MPR) was used to evaluate patients' adherence to medications, and repeated measure analysis was performed to reveal the pattern of variations. A Persian translation of Drug Attitude Inventory (DAI-10) (shortened version) was used to assess the attitude of patients toward medications.

Results: the repeated measure analysis revealed that the adherence to medications successively decreased (p<0.001). Age, gender, marital status, educational level, comorbid substance abuse did not alter the pattern.

Conclusion: There is a decreasing pattern in the adherence to medications among BID patients, regardless of known predicting factors of non-adherence. It means even fully adherent patients could potentially become non-adherents during the course of maintenance treatment.

Keywords

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