Depression in Hepatitis B and C, and Its Correlation With Hepatitis Drugs Consumption (Interfron/Lamivodin/Ribaverin)

Shahriar Alian; Abbas Masoudzadeh; Talayeh Khoddad; Amir Dadashian; Reza Ali Mohammadpour

IJ Psychiatry and Behavioral Sciences

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Depression in Hepatitis B and C, and Its Correlation With Hepatitis Drugs Consumption (Interfron/Lamivodin/Ribaverin)

Author(s):

Shahriar Alian¹,

Abbas Masoudzadeh²,

Talayeh Khoddad^3,*,

Amir Dadashian⁴,

Reza Ali Mohammadpour⁵

1Department of infectious disease, Mazandaran university of Medical Sciences, Sari, Iran

2Psychiatry and Behavioral Sciences Research Center, Department of Psychiatriy, Mazandaran University of Medical Science, Sari, Iran

3Clinical Research Development Unit of Imam Khomeini hospital, Mazandaran university of medical science, Iran

4Medical doctor, Mazandaran University of Medical Science, Iran

5Department of Biostatistics, Health Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran

IJ Psychiatry and Behavioral Sciences:Vol. 7, issue 1; 24-9

Published online:Jun 30, 2013

Article type:Research Article

Received:Feb 26, 2011

Accepted:Dec 08, 2012

How to Cite:Shahriar AlianAbbas MasoudzadehTalayeh Khoddad Amir DadashianReza Ali MohammadpourDepression in Hepatitis B and C, and Its Correlation With Hepatitis Drugs Consumption (Interfron/Lamivodin/Ribaverin).Iran J Psychiatry Behav Sci.7(1):24-9.

Abstract

Objective: Chronic infection of hepatitis B and hepatitis C are considered as the most important infectious diseases, which lead to drastic consequences such as liver dysfunction. Depression is a psychiatric disorder which is concomitantly present in these patients, and decreases the patients’ quality of life. It may lead to suicide, homicide or intentional transmission of infectious to others. Medical treatment with interferon can also lead to depression which is comparable to the depression caused by disease.

Methods: We performed a cross sectional study on 205 patients with hepatitis B and hepatitis C infection. We aimed to determine the prevalence of depression via Beck Depression Inventory (BDI), and its correlates with hepatitis drugs.

Results: Of 205 patients, 154 cases had hepatitis B and 51 cases had hepatitis C infection. The frequency of depression was 68% in hepatitis B and 86% in hepatitis C infected patients (p<0.05). The frequency of mild depression was 14%, moderate depression was 57.3% and severe depression was 28.7% (p<0.05). Depression frequency in Interferon recipients was 100%, in interferon-ribavirin recipients was 94.4%, in lamivudine recipients was 64%, and in patients that receive no drug was 66.7%. Depression prevalence was significantly higher among those on interferon therapy (p<0.05). Conclusion: There is a high prevalence of depression among patients with hepatitis B and hepatitis C infection, especially patients on interferon therapy. Hence these patients should be repeatedly evaluated for depression.

Declaration of Interest: None.

Citation: Alian S, Masoudzadeh A, Khoddad T, Dadashian A, Mohammadpour R. Depression in hepatitis B and C, and its correlation with hepatitis drugs consumption (Interferon/Lamivudine/Ribavirin). Iran J Psychiatry BehavSci 2013; 7(1): 24-9

Keywords

Chronic Hepatitis B

Chronic Hepatitis C

Depression Prevalence

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