Depression in Hepatitis B and C, and Its Correlation With Hepatitis Drugs Consumption (Interfron/Lamivodin/Ribaverin)

authors:

avatar Shahriar Alian 1 , avatar Abbas Masoudzadeh 2 , avatar Talayeh Khoddad 3 , * , avatar Amir Dadashian 4 , avatar Reza Ali Mohammadpour 5

Department of infectious disease, Mazandaran university of Medical Sciences, Sari, Iran
Psychiatry and Behavioral Sciences Research Center, Department of Psychiatriy, Mazandaran University of Medical Science, Sari, Iran
Clinical Research Development Unit of Imam Khomeini hospital, Mazandaran university of medical science, Iran
Medical doctor, Mazandaran University of Medical Science, Iran
Department of Biostatistics, Health Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran
Iranian Journal of Psychiatry and Behavioral Sciences: Vol.7, issue 1; 24-9
published online: June 30, 2013
article type: Original Article
received: February 26, 2011
revised: March 14, 2012
accepted: December 08, 2012

how to cite: Alian S, Masoudzadeh A, Khoddad T, Dadashian A, Ali Mohammadpour R. Depression in Hepatitis B and C, and Its Correlation With Hepatitis Drugs Consumption (Interfron/Lamivodin/Ribaverin). Iran J Psychiatry Behav Sci. 2013;7(1): 24-9. 

Abstract

Objective: Chronic infection of hepatitis B and hepatitis C are considered as the most important infectious diseases, which lead to drastic consequences such as liver dysfunction. Depression is a psychiatric disorder which is concomitantly present in these patients, and decreases the patients’ quality of life. It may lead to suicide, homicide or intentional transmission of infectious to others. Medical treatment with interferon can also lead to depression which is comparable to the depression caused by disease.
Methods: We performed a cross sectional study on 205 patients with hepatitis B and hepatitis C infection. We aimed to determine the prevalence of depression via Beck Depression Inventory (BDI), and its correlates with hepatitis drugs.
Results: Of 205 patients, 154 cases had hepatitis B and 51 cases had hepatitis C infection. The frequency of depression was 68% in hepatitis B and 86% in hepatitis C infected patients (p<0.05). The frequency of mild depression was 14%, moderate depression was 57.3% and severe depression was 28.7% (p<0.05). Depression frequency in Interferon recipients was 100%, in interferon-ribavirin recipients was 94.4%, in lamivudine recipients was 64%, and in patients that receive no drug was 66.7%. Depression prevalence was significantly higher among those on interferon therapy (p<0.05). Conclusion: There is a high prevalence of depression among patients with hepatitis B and hepatitis C infection, especially patients on interferon therapy. Hence these patients should be repeatedly evaluated for depression.
Declaration of Interest: None.
Citation: Alian S, Masoudzadeh A, Khoddad T, Dadashian A, Mohammadpour R. Depression in hepatitis B and C, and its correlation with hepatitis drugs consumption (Interferon/Lamivudine/Ribavirin). Iran J Psychiatry BehavSci 2013; 7(1): 24-9

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