Topiramate Add-on Lithium Carbonate for Treatment of Acute Mania

2Psychiatrist, Associate Professor, Department of Psychiatry, Razi Psychiatric Hospital, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

3Clinical Psychologist, Assistant Professor, Department of Psychiatry, Razi Psychiatric Hospital, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

4Psychiatrist, Assistant Professor, Department of Psychiatry, Razi Psychiatric Hospital, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

IJ Psychiatry and Behavioral Sciences:Vol. 7, issue 2; 11-5

Published online:Dec 30, 2013

Article type:Research Article

Received:Feb 28, 2013

Accepted:Sep 19, 2013

How to Cite:Zahra MirsepassiRobabeh MazinaniFarbod FadaiNeda AlibeigiAli Nazeri-AstanehTopiramate Add-on Lithium Carbonate for Treatment of Acute Mania.Iran J Psychiatry Behav Sci.7(2):11-5.

Abstract

Objective: The purpose of this study was to evaluate the effect of adjunctive topiramate in treating acute mania.

Methods: In this study which was a double-blinded randomized clinical trial, 46 bipolar patients in manic episode, were treated with lithium carbonate and topiramate versus lithium carbonate and placebo and treatment responses were assessed by Young Mania Rating Scale (YMRS) weekly.

Results: In both intervention and control groups, YMRS score had significant decline after 8 weeks (p < 0.001), but there was no statistically significant difference between the two groups (p = 0.419). The highest score decline was after two weeks. YMRS score at baseline did not have statistically significant difference between the intervention and control groups (p = 0.709).

Conclusions: This study failed to show antimanic efficacy of adjunctive topiramate in the treatment of those with acute manic.

Declaration of interest: None. Clinical Trial Registration: URL: http://www.irct.ir. IRCT201110317960N1.

Citation: Mirsepassi Z, Mazinani R, Fadai F, Alibeigi N, Nazeri-Astaneh A. Topiramate add-on lithium carbonate for treatment of acute mania. Iran J Psychiatry Behav Sci 2013; 7(2): 11-5

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