Depot Typical Antipsychotics versus Oral Atypical Antipsychotics in Relapse Rate Among Patients with Schizophrenia: A Five -Year Historical Cohort Study

Hamid-Reza Ahmadkhaniha; Shahab Bani-Hashem; Masoud Ahmadzad-Asl

IJ Psychiatry and Behavioral Sciences

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Depot Typical Antipsychotics versus Oral Atypical Antipsychotics in Relapse Rate Among Patients with Schizophrenia: A Five -Year Historical Cohort Study

Author(s):

Hamid-Reza Ahmadkhaniha^1,*,

Shahab Bani-Hashem²,

Masoud Ahmadzad-Asl³

1Research Center, Tehran Psychiatry Institute, Tehran University of Medical Sciences and Health Services, Tehran, Iran

2Psychiatrist, Department of Psychiatry, School of Medicine, Kerman University of Medical Sciences and Health Services, Kerman, Iran

3Assistant Professor, Department of Psychiatry, Mental Health Research Center, Tehran Psychiatry Institute, Tehran University of Medical Sciences and Health Services, Tehran, Iran

IJ Psychiatry and Behavioral Sciences:Vol. 8, issue 1; 66-71

Published online:Mar 30, 2014

Article type:Research Article

Received:Feb 04, 2012

Accepted:Jan 13, 2014

How to Cite:Hamid-Reza Ahmadkhaniha, Shahab Bani-Hashem, Masoud Ahmadzad-Asl, Depot Typical Antipsychotics versus Oral Atypical Antipsychotics in Relapse Rate Among Patients with Schizophrenia: A Five -Year Historical Cohort Study.Iran J Psychiatry Behav Sci.2014;8(1):66-71.

Abstract

Objective: The present study aimed to review the relapse rate in patients with schizophrenia treated with orally taken atypical agents (serotonin dopamine antagonists, SDAs) and depot preparation of conventional (typical) antipsychotics.

Methods: In this historical cohort study, mean relapse per month (MRM) index, duration between initiation of antipsychotic treatment and the first relapse episode, and the time gap between successive relapses were compared between 84 patients on SDAs-except clozapine (group 1) and 81 others on depot typical antipsychotics (group 2).

Results: The two groups were comparable regarding mean (±SD) MRM index [0.033 (±0.004) in group1 and 0.044 (±0.05) in group 2; p = 0.345]. Mean (±SD) duration of time between initiation of maintenance treatment and the first relapse was 15.5 (±13.67) months in group 1 and 16.40 (±15.31) months in group 2, (p = 0.876). Mean (±SD) duration of remission periods between successive relapses were 17.92 (±14.2) and 15.8 (±16.9) months for group 1 and group 2, respectively (Mann-Whitney test, (p = 0.048).

Conclusion: Orally taken atypical antipsychotics were able to keep the duration of remission periods between successive relapses more prolonged compared to depot conventional preparations. This could be added to their other remarkable benefits especially if the patient is expected to experience multiple relapses.

Declaration of interest: None.

Citation: Ahmadkhaniha HR, Bani-Hashem Sh, Ahmadzad-Asl M. Depot typical antipsychotics versus oral atypical antipsychotics in relapse rate among patients with schizophrenia: A five- year historical Cohort study. Iran J Psychiatry Behav Sci 2014; 8(1): 66-71.

Keywords

Antipsychotic Agents

Dopamine Receptor Antagonists

Long-Acting Drugs

Schizophrenia

Serotonin Dopamine Antagonists

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