Amperometric Determination of Ascorbic Acid in Pharmaceutical Formulations by a Reduced Graphene Oxide-cobalt Hexacyanoferrate Nanocomposite

Hossein Heli; Naghmeh Sattarahmady

doi:10.22037/ijpr.2015.1645

IJ Pharmaceutical Research

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https://doi.org/10.22037/ijpr.2015.1645

Amperometric Determination of Ascorbic Acid in Pharmaceutical Formulations by a Reduced Graphene Oxide-cobalt Hexacyanoferrate Nanocomposite

Author(s):

Hossein Heli^{1, 2,*},

Naghmeh Sattarahmady^{1, 2, 3}

1Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

2Department of Nanomedicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran

3Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

IJ Pharmaceutical Research:Vol. 14, issue 2; 453-463

Published online:Aug 12, 2022

Article type:Research Article

Received:Oct 01, 2013

Accepted:May 01, 2014

How to Cite:Hossein HeliNaghmeh SattarahmadyAmperometric Determination of Ascorbic Acid in Pharmaceutical Formulations by a Reduced Graphene Oxide-cobalt Hexacyanoferrate Nanocomposite.Iran J Pharm Res.14(2):e125360.https://doi.org/10.22037/ijpr.2015.1645.

Abstract

Investigation of the redox properties of drugs and their determination are performed by electrochemical techniques. Data obtained from electrochemical techniques are often correlated with molecular structure and pharmacological activity of drugs. In this regard, different modified electrodes were applied as sensors for quantification of different drugs.

A nanocomposite of reduced graphene oxide-cobalt hexacyanoferrate was synthesized by a simple precipitation route. Scanning electron microscopy revealed that the nanocomposite comprised nanoparticles of cobalt hexacyanoferrate attached to the reduced graphene oxide nanosheets. A nanocomposite-modified carbon paste electrode was then fabricated. It represented prominent activity toward the electrocatalytic oxidation of ascorbic acid, and the kinetics of the electrooxidation process was evaluated. Finally, an amperometric method was developed for the quantification of ascorbic acid in different pharmaceutical formulations.

Keywords

Electroanalysis

Ascorbic acid

Nanocomposite

Cobalt hexacyanoferrate

Reduced graphene oxide

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Author(s):

Hossein Heli:[PubMed][Scholar]
Naghmeh Sattarahmady:[PubMed][Scholar]