Gelatin Microspheres for the Controlled Release of All-trans-Retinoic Acid Topical Formulation and Drug Delivery Evaluation

authors:

avatar Rasool Dinarvand 1 , * , avatar Elham Rahmani 1 , avatar Efat Farbod 1

Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Iranian Journal of Pharmaceutical Research: Vol.2, issue 1; 47-50
published online: November 20, 2010
article type: Research Article
received: November 01, 2002
accepted: February 01, 2003
DOI: https://doi.org/10.22037/ijpr.2010.35

how to cite: Dinarvand R, Rahmani E, Farbod E. Gelatin Microspheres for the Controlled Release of All-trans-Retinoic Acid Topical Formulation and Drug Delivery Evaluation. Iran J Pharm Res. 2003;2(1):e127609. https://doi.org/10.22037/ijpr.2010.35.

Abstract

A topical o/w cream containing tretinoin microspheres was prepared. Gelatin microspheres of tretinoin were prepared using coacervation method. These microspheres contained about 50% w/w tretinoin. The particle size range of microspheres was between 90-150 µm. In vitro drug release from microspheres and a cream formulation was studied. It was shown that drug release from microspheres followed Higuchi kinetics of release. However, drug release from the cream formulation followed zero order release profile.