Reduction of Some Atherogenic Indices in Patients with Non-Alcoholic Fatty Liver by Vitamin D and Calcium Co-Supplementation: A Double Blind Randomized Controlled Clinical Trial

Farzad Shidfar; Seyedeh Neda Mousavi; Hamid lorvand Amiri; Shahram Agah; Sharieh Hoseini; Seyed Javad Hajimiresmai

doi:10.22037/ijpr.2019.2357

IJ Pharmaceutical Research

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https://doi.org/10.22037/ijpr.2019.2357

Reduction of Some Atherogenic Indices in Patients with Non-Alcoholic Fatty Liver by Vitamin D and Calcium Co-Supplementation: A Double Blind Randomized Controlled Clinical Trial

Author(s):

Farzad Shidfar^{1, 2},

Seyedeh Neda Mousavi^3,*,

Hamid lorvand Amiri⁴,

Shahram Agah²,

Sharieh Hoseini⁵,

Seyed Javad Hajimiresmai⁶

1Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

2Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran

3Department of Nutrition, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

4Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

5Department of Applied chemistry, Faculty of Pharmaceutical Chemistry, Pharmaceutical Sciences Branch, Isalmic Azad University, Tehran, Iran

6Department of Cardiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

IJ Pharmaceutical Research:Vol. 18, issue 1; 496-505

Published online:May 01, 2018

Article type:Research Article

Received:Apr 01, 2017

Accepted:May 01, 2018

How to Cite:Farzad ShidfarSeyedeh Neda MousaviHamid lorvand AmiriShahram AgahSharieh HoseiniSeyed Javad Hajimiresmaiet al.Reduction of Some Atherogenic Indices in Patients with Non-Alcoholic Fatty Liver by Vitamin D and Calcium Co-Supplementation: A Double Blind Randomized Controlled Clinical Trial.Iran J Pharm Res.18(1):e127857.https://doi.org/10.22037/ijpr.2019.2357.

Abstract

The role of non-alcoholic fatty liver disease (NAFLD) as a potential independent cardiovascular disease (CVD) risk factor has recently gained considerable attention because CVD is the common cause of death in NAFLD patients. We aimed to estimate the effects of vitamin D supplementation alone or in combination with calcium on atherogenic indices, liver function tests, and grade of disease in patients with NAFLD. One-hundred twenty NAFLD patients were randomized in a double-blind, placebo-controlled clinical trial as follows: D (1000 IU vitamin D), CaD (500 mg as calcium carbonate plus 1000 IU vitamin D) or P (placebo), once daily with meals over 12 weeks. Adjusted for all the baseline measures, reduction in serum ALT, AST, LDL-C/HDL-C, TC/HDL-C, and non-HDL-C were significantly higher in the CaD compared with the P group (p < 0.001, p = 0.03, p < 0.001, p < 0.001, p < 0.001 and p < 0.001, respectively). Also, mean difference of serum ALT, LDL-C/HDL-C, TC/HDL-C, and TG/HDL-C were significantly higher in the CaD than D group (p < 0.001, p = 0.006, p < 0.001 and p = 0.03, respectively). Serum non-HDL-C was marginally decreased in the CaD compared with the D group (p = 0.06). With considering the BMI changes as covariate, reduction in the grade of fatty liver was significantly higher in the CaD and D groups than the P (p < 0.001). The present study suggests that supplemental calcium combined with vitamin D, but not vitamin D alone, may reduce serum atherogenic indices, liver function tests, and grade of disease in patients with NAFLD.

Keywords

Calcium

Vitamin D

Atherogenic indices

Non-alcoholic fatty liver

Supplementation

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Author(s):

Farzad Shidfar:[PubMed][Scholar]
Seyedeh Neda Mousavi:[PubMed][Scholar]
Hamid lorvand Amiri:[PubMed][Scholar]
Shahram Agah:[PubMed][Scholar]
Sharieh Hoseini:[PubMed][Scholar]
Seyed Javad Hajimiresmai:[PubMed][Scholar]