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IJ Pharmaceutical Research

e-ISSN 1726-6890
p-ISSN 1735-0328
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Latest issue

76 articlesJanuary - DecemberVol. 25Issue 1XML
21
Jul
2026
Synthesis and Preclinical Evaluation of 188Re-MAX-HEDP: A Promising Theranostics Strategy for Bone Metastases
Research Article

Synthesis and Preclinical Evaluation of 188Re-MAX-HEDP: A Promising Theranostics Strategy for Bone Metastases

Sarah Shoohani,
Saeed KakaeiORCID*,
Elham Sattarzadeh Khameneh,
Fariba Johari Daha,
Mojtaba Tajik**
PDFUncorrected Proof
20
Jul
2026
Pharmacophore-Based Virtual Screening for Identification of Adenosine Deaminase Inhibitors
Research Article

Pharmacophore-Based Virtual Screening for Identification of Adenosine Deaminase Inhibitors

Saba Ahmadi,
Mona Khoramjouy,
Arefeh Jafarian,
Soraya Shahhosseini,
Salimeh AmidiORCID*,
Farzad KobarfardORCID**
PDFFinal Published
18
Jul
2026
Integrative Network Analysis of Bioactive Compounds from Punica granatum L. Peel: Multi-Target Mechanisms in Wound Healing
Research Article

Integrative Network Analysis of Bioactive Compounds from Punica granatum L. Peel: Multi-Target Mechanisms in Wound Healing

Seyyed Shahab ShokriORCID,
Ebrahim Salimi SabourORCID*,
Seyed Morteza HosseiniORCID,
Hossein Reza ShateriORCID
PDFUncorrected Proof
13
Jul
2026
Synthesis and Evaluation of the Effects of Nanoparticles of Atorvastatin and Atorvastatin on Cuprizone-Induced Demyelination: Modulation of the Nrf2/NF-kB Signaling Pathway
Research Article

Synthesis and Evaluation of the Effects of Nanoparticles of Atorvastatin and Atorvastatin on Cuprizone-Induced Demyelination: Modulation of the Nrf2/NF-kB Signaling Pathway

Samira ShirooieORCID*,
Niloofar Heidarizade,
Tayebeh Noori,
Antoni Sureda,
Amin Iranpanah,
Sina Alibeygi
PDFFinal Published
7
Jul
2026
Neuroprotective Effects of Empagliflozin Against Methamphetamine-Induced Withdrawal Syndrome in Mice: Involvement of Bdnf, Tlr4, and JNK Signaling Pathways and Oxidative Stress Biomarkers
Research Article

Neuroprotective Effects of Empagliflozin Against Methamphetamine-Induced Withdrawal Syndrome in Mice: Involvement of Bdnf, Tlr4, and JNK Signaling Pathways and Oxidative Stress Biomarkers

Hamed GhavimiORCID,
Mina Ebrahimi,
Maede Hasanzadeh,
Alireza Lashgari,
Keivan Nedaei,
Ali Kalantari Hesari
,et al.
PDFUncorrected Proof
4
Jul
2026
Silymarin Exerts Potent Antipruritic Effects Against Chloroquine-Induced Scratching in Mice by Modulating the NO/NF-κB/TRPA1 Pathway
Research Article

Silymarin Exerts Potent Antipruritic Effects Against Chloroquine-Induced Scratching in Mice by Modulating the NO/NF-κB/TRPA1 Pathway

Hosna BagheriORCID,
Amir KianiORCID,
Mohammad Amin Ali Mohammad Golesorkhi,
Antoni Sureda,
Samira ShirooieORCID*
PDFFinal Published
28
Jun
2026
Overcoming Liability of Outsidership Under Sanctions: A Capability-Based Framework from Emerging Market Pharmaceuticals
Research Article

Overcoming Liability of Outsidership Under Sanctions: A Capability-Based Framework from Emerging Market Pharmaceuticals

Sheida PaknejadORCID*,
Mahdi Mohammadzadeh
PDFFinal Published
28
Jun
2026
Exploration of Endophytic Fungal Communities in Three Hypericum Species: Molecular Identification and Evaluation of Antibacterial Activity Against Clinically Relevant Pathogens
Research Article

Exploration of Endophytic Fungal Communities in Three Hypericum Species: Molecular Identification and Evaluation of Antibacterial Activity Against Clinically Relevant Pathogens

Fahimeh Nabi,
Ahmad Asgharzadeh*,
Javad Asili,
Abolfazl Shakeri**
PDFFinal Published
28
Jun
2026
Renoprotective Effects of Allium jesdianum Against Cyclophosphamide: Role of Antioxidant Enzymes and Pro-inflammatory Cytokines in a Murine Model
Research Article

Renoprotective Effects of Allium jesdianum Against Cyclophosphamide: Role of Antioxidant Enzymes and Pro-inflammatory Cytokines in a Murine Model

Alireza Rezaei,
Bahareh Sadat Yousefsani,
Ameneh OmidiORCID,
Kobra ShiraniORCID*
PDFFinal Published
21
Jun
2026
Impact of Family Planning Program on Related Drug Consumption in Iran: A Ten-Year Trend Analysis (2014 - 2023)
Research Article

Impact of Family Planning Program on Related Drug Consumption in Iran: A Ten-Year Trend Analysis (2014 - 2023)

Matin JafariORCID*
PDFFinal Published
21
Jun
2026
Synthesis of Methoxy Amido Xanthate Ligand and Preliminary Rhenium-188 Radiolabeling Studies
Research Article

Synthesis of Methoxy Amido Xanthate Ligand and Preliminary Rhenium-188 Radiolabeling Studies

Ali Ashrfi Goudarzi,
Mehdi Salehi BaroughORCID*,
Leila Moghaddam-BanaemORCID**,
Saeed Kakaei,
Fariba Johari DahaORCID
PDFFinal Published
17
Jun
2026
Hesperetin Attenuates Liver Fibrosis in Mice by Modulating Selected Gut Microbial Populations and SIRT2-Associated Inflammatory Signaling
Research Article

Hesperetin Attenuates Liver Fibrosis in Mice by Modulating Selected Gut Microbial Populations and SIRT2-Associated Inflammatory Signaling

Anzhao Wu,
Lingjie Xin,
Yuji Liang,
Luyan Sun,
Qian Liu,
Bin Wang
,et al.
PDFFinal Published
17
Jun
2026
Evaluation of the Protective Effect of n-Hexane Oil Extract of Black Soldier Fly Larvae on Oxidative Stress, Inflammation, and Signaling Pathway Alterations in Acrylamide-Induced Hepatotoxicity in Rats
Research Article

Evaluation of the Protective Effect of n-Hexane Oil Extract of Black Soldier Fly Larvae on Oxidative Stress, Inflammation, and Signaling Pathway Alterations in Acrylamide-Induced Hepatotoxicity in Rats

Yalda Arast,
Arash Parvaresh,
Somaye Behnamipour,
Fateme HeidariORCID,
Tahereh Zarei Taher,
Jalal PourahmadORCID*
PDFFinal Published
16
Jun
2026
Discovery of Phthalazine Derivatives as New PARP1 Inhibitors Through 3D-QSAR, Molecular Docking, and MD Studies
Research Article

Discovery of Phthalazine Derivatives as New PARP1 Inhibitors Through 3D-QSAR, Molecular Docking, and MD Studies

Tahereh Sedghamiz*,
Somayeh Asgharpour Hasan Kiyadeh,
Fatemeh Moosavi,
Alireza Poustforoosh
PDFFinal Published
16
Jun
2026
Deciphering the Anticancer Effects of Baicalein in Human Gastric Cancer Cells: Computational Chemistry, Bioinformatics, Network Pharmacology Insights, and in vitro Experimental Validation
Research Article

Deciphering the Anticancer Effects of Baicalein in Human Gastric Cancer Cells: Computational Chemistry, Bioinformatics, Network Pharmacology Insights, and in vitro Experimental Validation

Bai Jing,
Ren Hui,
Li Xiao*
PDFFinal Published
15
Jun
2026
Hepatic Inflammation and Apoptosis in Socially Isolated Rats: Effects of Vortioxetine Treatment
Research Article

Hepatic Inflammation and Apoptosis in Socially Isolated Rats: Effects of Vortioxetine Treatment

Neziha Senem ArıORCID*,
Merve AkkuşORCID,
Hatice SolakORCID,
Raviye Özen KocaORCID,
Işık Solak GörmüşORCID
PDFFinal Published
14
Jun
2026
Preparation and Evaluation of Zn2(BDC)2(DABCO)-β-CD MOF as a Dual-Drug Delivery Nanocomposite Containing Tetracycline and Indomethacin for Skin Wound Healing in BALB/c Mice
Research Article

Preparation and Evaluation of Zn2(BDC)2(DABCO)-β-CD MOF as a Dual-Drug Delivery Nanocomposite Containing Tetracycline and Indomethacin for Skin Wound Healing in BALB/c Mice

Farya Mirzaei,
Negar Motakef KazemiORCID*,
Naser Mohamadpour Dounighi,
Mostafa Saffari,
Sepideh Arbabi Bidgoli
PDFFinal Published
14
Jun
2026
Hepatoprotective Effects of Ethyl Acetate Extract of Lygodium microphyllum Leaves
Research Article

Hepatoprotective Effects of Ethyl Acetate Extract of Lygodium microphyllum Leaves

Hadi KuncoroORCID*,
Erna Muliana,
Putri AnggreiniORCID,
Angga Cipta NarsaORCID,
Zulhaerana BaharORCID,
Vina MaulidyaORCID
,et al.
PDFFinal Published
13
Jun
2026
Comparison of Naringenin and Alendronate in the Attenuation of Ovariectomy-Induced Osteoporosis by Modulating Autophagy, Apoptosis, and Oxidative Stress in Rats
Research Article

Comparison of Naringenin and Alendronate in the Attenuation of Ovariectomy-Induced Osteoporosis by Modulating Autophagy, Apoptosis, and Oxidative Stress in Rats

Hongwei Gao,
Pengcheng Ma,
Huizhi Chen,
Zhengkai Zhang,
Nara Davtyan,
Jiachun Zheng*
PDFUncorrected Proof
13
Jun
2026
CRISPR/Cas9-Engineered HEK293T Cellular Model Harboring the Pathogenic CDKL5 c.172A>T Variant Recapitulates Core Molecular Phenotypes of CDKL5 Deficiency Disorder
Research Article

CRISPR/Cas9-Engineered HEK293T Cellular Model Harboring the Pathogenic CDKL5 c.172A>T Variant Recapitulates Core Molecular Phenotypes of CDKL5 Deficiency Disorder

Fatemeh Faghihi,
Jafar AmaniORCID*,
Milad GholamiORCID,
Iman SalahshourifarORCID
PDFFinal Published
10
Jun
2026
Pharmacological SIRT1 Inhibition Exacerbates Angiotensin II-Induced Myocardial Injury and Is Associated with Dysregulation of the p53-FOXO3a Stress-Response Axis
Research Article

Pharmacological SIRT1 Inhibition Exacerbates Angiotensin II-Induced Myocardial Injury and Is Associated with Dysregulation of the p53-FOXO3a Stress-Response Axis

Lijuan Song,
Umar Saeed,
Zahra Zahid Piracha,
Dilber Uzun Ozsahin,
İlker Özşahin,
Rizwan Uppal
,et al.
PDFFinal Published
9
Jun
2026
Novel Ethyl 2-Aminopyrano[3,2-c]isochromene-3-carboxylate Derivatives: Synthesis, Spectral Characterization, and Cytotoxicity
Research Article

Novel Ethyl 2-Aminopyrano[3,2-c]isochromene-3-carboxylate Derivatives: Synthesis, Spectral Characterization, and Cytotoxicity

Mehdi AbaszadehORCID,
Fatemeh Haghani,
Ehsan Faghihmirzaei,
Salehe SabouriORCID*
PDFFinal Published
9
Jun
2026
Buyang Tongluo Decoction Mitigates Acute Ischemic Stroke by Suppressing NLRP3/Caspase-1/GSDMD Pathway-Induced Pyroptotic Cell Death
Research Article

Buyang Tongluo Decoction Mitigates Acute Ischemic Stroke by Suppressing NLRP3/Caspase-1/GSDMD Pathway-Induced Pyroptotic Cell Death

Hai Lin,
Yi Liu,
Yongjie Gao,
Weiyu Xu,
Qi Li,
Min Li
,et al.
PDFFinal Published
8
Jun
2026
Efficacy of a Saffron-Based (Crocus sativus L.) Herbal Supplement on Sleep Disturbances in Pulmonary Sarcoidosis: A Randomized Single-Blind Controlled Trial
Research Article

Efficacy of a Saffron-Based (Crocus sativus L.) Herbal Supplement on Sleep Disturbances in Pulmonary Sarcoidosis: A Randomized Single-Blind Controlled Trial

Zahra Moghimi DehkordiORCID,
Jamshid SalamzadehORCID,
Maria Tavakoli-ArdakaniORCID,
Atefeh AbediniORCID,
Farzaneh DastanORCID*
PDFFinal Published
6
Jun
2026
Pharmacologic Sedation–Related Respiratory Complications in Pediatric Dentistry: A Decade-Long Scoping Review
Review Article

Pharmacologic Sedation–Related Respiratory Complications in Pediatric Dentistry: A Decade-Long Scoping Review

Leila Mohammadpour-BelvirdyORCID,
Elham SadatiORCID,
Maryam HassanzadORCID*,
Ali ValinejadiORCID**
PDFFinal Published
3
Jun
2026
Integrative Network Pharmacology and Experimental Validation Reveal Multi-target Hepatoprotective Mechanisms of Bioactive Compounds from Xiao-Yao-San
Research Article

Integrative Network Pharmacology and Experimental Validation Reveal Multi-target Hepatoprotective Mechanisms of Bioactive Compounds from Xiao-Yao-San

Zi-Yi ZhengORCID,
Jing-Yi ChenORCID,
Roy You Chen QuahORCID,
Guo-Hua DingORCID*,
Jing ChenORCID**
PDFFinal Published
2
Jun
2026
Berberine Alleviates Hepatic Steatosis by Restoring CPT1α Histone Acetylation and Modulating HDAC2/SIRT2
Research Article

Berberine Alleviates Hepatic Steatosis by Restoring CPT1α Histone Acetylation and Modulating HDAC2/SIRT2

Chenye Shi,
Shuai Ma,
Hua Bian,
Qiong Liu,
Huandong Lin,
Xin Gao
,et al.
PDFFinal Published
2
Jun
2026
RNA-Seq Analysis of Morphine-Induced Gene Expression Changes in the Mouse Nucleus Accumbens
Research Article

RNA-Seq Analysis of Morphine-Induced Gene Expression Changes in the Mouse Nucleus Accumbens

Seyed Mahmoud PourmandORCID,
Shahrzad Nazari,
Elham NazariORCID,
Reza Arezoomandan,
Gholamreza Hassanzadeh,
Sahar EshratiORCID
,et al.
PDFFinal Published
30
May
2026
miR-146a-Enriched Mesenchymal Stem Cell-Derived Extracellular Vesicles Prolong Corneal Allograft Survival by Modulating Local and Systemic Immune Responses
Research Article

miR-146a-Enriched Mesenchymal Stem Cell-Derived Extracellular Vesicles Prolong Corneal Allograft Survival by Modulating Local and Systemic Immune Responses

Xuting He*
PDFFinal Published
26
May
2026
Dendrobium officinale Polysaccharide Promotes Infected Wound Healing Through SIRT1-Regulated HMGB1-K29 Deacetylation and NF-κB Inhibition
Research Article

Dendrobium officinale Polysaccharide Promotes Infected Wound Healing Through SIRT1-Regulated HMGB1-K29 Deacetylation and NF-κB Inhibition

Yutong Wu,
Mohd Hasmizam Razali,
Wentao Wu*
PDFFinal Published
26
May
2026
Investigating the Anti-inflammatory Mechanism of Alpinia purpurata (Vieill.) K. Schum. Rhizome Extract: Metabolite Profiling, Network Pharmacology, in vitro Safety, and in vivo Validation
Research Article

Investigating the Anti-inflammatory Mechanism of Alpinia purpurata (Vieill.) K. Schum. Rhizome Extract: Metabolite Profiling, Network Pharmacology, in vitro Safety, and in vivo Validation

Kiki Mulkiya Yuliawati,
Fahriza Salsabilla Yuniar,
Ellin FebrinaORCID,
Gofarana WilarORCID,
Raden Maya FebriyantiORCID*,
Deshanda Kurniawan Prayoga
,et al.
PDFFinal Published
26
May
2026
A New Survey about Dual-Acting PARP/COX-2 Inhibitors as Cancer Chemopreventive Agents
Review Article

A New Survey about Dual-Acting PARP/COX-2 Inhibitors as Cancer Chemopreventive Agents

Mohammad Ismail Mahboubi Rabbani,
Ali Aliabadi,
Leila Bayat,
Mahdokht Jafari,
Amir Hossein Bagheri,
Sarah Shateri
,et al.
PDFFinal Published
25
May
2026
In silico Identification of Natural Compounds as Potential TrkA Inhibitors for Anticancer Drug Development
Research Article

In silico Identification of Natural Compounds as Potential TrkA Inhibitors for Anticancer Drug Development

Mujtaba Fadhil,
Dhurgham Al-Fahad*,
Faizul Azam,
Asadollah AsadiORCID**
PDFFinal Published
24
May
2026
Tanshinone IIA Alleviates Mitochondrial Dysfunction in Lipopolysaccharide-Induced Acute Kidney Injury in Mice by Activating SIRT1/PINK1-Mediated Mitophagy
Research Article

Tanshinone IIA Alleviates Mitochondrial Dysfunction in Lipopolysaccharide-Induced Acute Kidney Injury in Mice by Activating SIRT1/PINK1-Mediated Mitophagy

Xiaoli Guo,
Yi Gao,
Rami B. Kassab,
Fangdi Zhang*
PDFFinal Published
23
May
2026
Efficacy of Nanocurcumin in Preventing Paclitaxel-Induced Peripheral Neuropathy Among Breast Cancer Patients: Findings from a Double-Blind, Randomized, Placebo-Controlled Clinical Trial
Research Article

Efficacy of Nanocurcumin in Preventing Paclitaxel-Induced Peripheral Neuropathy Among Breast Cancer Patients: Findings from a Double-Blind, Randomized, Placebo-Controlled Clinical Trial

Behzad Norouzi,
Majid GhasemiORCID,
Valiollah MehrzadORCID,
Mohammadreza Khosravifarsani,
Marjan MansourianORCID,
Azadeh Moghaddas*
PDFFinal Published
23
May
2026
Design, Synthesis, Molecular Docking, and Preclinical Evaluation of a New Radiolabeled PEG3-Linked FAPI Derivative for Fibroblast Activation Protein Targeting
Research Article

Design, Synthesis, Molecular Docking, and Preclinical Evaluation of a New Radiolabeled PEG3-Linked FAPI Derivative for Fibroblast Activation Protein Targeting

Mahshid Kiani,
Mehdi Akhlaghi,
Safura Jokar,
Omid Bavi,
Hooman Hafezi,
Khosrou Abdi
,et al.
PDFFinal Published
20
May
2026
Adjunct Low-Dose Dexmedetomidine for Sedation in Mechanically Ventilated Children: An Exploratory Randomized Trial
Research Article

Adjunct Low-Dose Dexmedetomidine for Sedation in Mechanically Ventilated Children: An Exploratory Randomized Trial

Amir Farrokhian,
Najmeh Forouzan,
Bahador MirrahimiORCID,
Seyyedeh Masumeh HashemiORCID,
Alireza Kargar,
Maryam Alemzadeh
,et al.
PDFFinal Published
20
May
2026
Metformin Attenuates Angiotensin II-Induced Cardiac Inflammaging-Like Injury Through Coordinated Nrf2 Activation and NF-κB Suppression
Research Article

Metformin Attenuates Angiotensin II-Induced Cardiac Inflammaging-Like Injury Through Coordinated Nrf2 Activation and NF-κB Suppression

Huarui Li,
Deming Fu,
Umar Saeed,
Zahra Zahid Piracha,
Jianjun Bao*
PDFFinal Published
20
May
2026
Elucidating the Molecular Mechanisms of Angelica sinensis Against Hepatocellular Carcinoma Through Network Pharmacology, in silico Molecular Docking, and in vitro Validation
Research Article

Elucidating the Molecular Mechanisms of Angelica sinensis Against Hepatocellular Carcinoma Through Network Pharmacology, in silico Molecular Docking, and in vitro Validation

Huajun WuORCID,
Ping LuoORCID,
Chongming ShenORCID*
PDFFinal Published
19
May
2026
Andrographolide Alleviates Mycoplasma pneumoniae Pneumonia in Children by Inhibiting Alveolar Epithelial Cell Pyroptosis Through the HMGB1/TLR4/NF-κB Pathway
Research Article

Andrographolide Alleviates Mycoplasma pneumoniae Pneumonia in Children by Inhibiting Alveolar Epithelial Cell Pyroptosis Through the HMGB1/TLR4/NF-κB Pathway

Lijuan Zhang,
Umar Saeed,
Rui Gao*
PDFFinal Published
19
May
2026
Apigenin for Depression and Anxiety: A Systematic Review of Preclinical Studies
Systematic Review

Apigenin for Depression and Anxiety: A Systematic Review of Preclinical Studies

Jin Wang,
Kun Shi*
PDFFinal Published
17
May
2026
The Impact of Marijuana (Cannabis sativa) on Viability and Expression of Cardiac Markers in Human Cardiomyocytes
Research Article

The Impact of Marijuana (Cannabis sativa) on Viability and Expression of Cardiac Markers in Human Cardiomyocytes

Hossein Kargar JahromiORCID,
Vida Khalafi,
Vida Mirzaei,
Faezeh Ebrahimi-Zadeh,
Pouria Azami,
Tara Abdolahy
,et al.
PDFFinal Published
15
May
2026
External Knowledge Search and Innovation Performance in Iranian Biopharmaceutical Firms: The Mediating Role of Knowledge Integration Capability
Research Article

External Knowledge Search and Innovation Performance in Iranian Biopharmaceutical Firms: The Mediating Role of Knowledge Integration Capability

Fatemeh BabaeiORCID,
Nazila YousefiORCID*,
Mohammad PeikanpourORCID
PDFFinal Published
4
May
2026
Pharmacological SIRT2 Inhibition by AGK2 Attenuates Hapten-Induced Keratinocyte Inflammation via NF-κB/NLRP3 Suppression and Nrf2 Reactivation
Research Article

Pharmacological SIRT2 Inhibition by AGK2 Attenuates Hapten-Induced Keratinocyte Inflammation via NF-κB/NLRP3 Suppression and Nrf2 Reactivation

Xianhua QiaoORCID,
Xinglong YuORCID,
Juanjuan GaoORCID,
Chong Lv,
Fang ChengORCID*
PDFFinal Published
4
May
2026
The Role of Methylacrylylated Hyaluronic Acid Hydrogels in Promoting Skin Wound Healing
Research Article

The Role of Methylacrylylated Hyaluronic Acid Hydrogels in Promoting Skin Wound Healing

Chunfang Zheng,
Waifung Mai,
Liqi Zou,
Lianying Li,
Bingwei Sun*
PDFFinal Published
4
May
2026
Four Steroidal Saponins Isolated from the Aerial Parts of Allium jesdianum Exhibit Antibiofilm Effects Against Colistin-Resistant Clinical Strains, with an In Silico Study
Research Article

Four Steroidal Saponins Isolated from the Aerial Parts of Allium jesdianum Exhibit Antibiofilm Effects Against Colistin-Resistant Clinical Strains, with an In Silico Study

Saeid EslamiORCID,
Behzad ZolfaghariORCID,
Masoud Sadeghi Dinani,
Arezoo Mirzaee,
Hajar Sirous,
Mustafa GhanadianORCID*
PDFFinal Published
4
May
2026
Evaluation of Mesna Co-administration in the Management of Acute Pancreatitis: A Pilot Randomized Clinical Trial
Research Article

Evaluation of Mesna Co-administration in the Management of Acute Pancreatitis: A Pilot Randomized Clinical Trial

Amir Sadeghi,
Mohammad-Yousef Fazel,
Mohammad Abbasinazari*,
Laleh Mahmoudi,
Seyed-Mehregan Sadatsafavi,
Parvaneh MohammadiORCID
PDFFinal Published
28
Apr
2026
Research Article

Photodynamic Therapy Combined with Gemcitabine for Prostate Cancer Using Nanoprobe for in-vivo CEST Imaging

Qibo Fu,
Qian Liu,
Xianyou Zeng,
Laoji Wang,
Jierou Yan,
Ding He
,et al.
PDFFinal Published
28
Apr
2026
Baicalein Protects H9c2 Cardiomyoblasts Against LPS-Induced Inflammatory Injury by Modulating the NF-κB/NLRP3 Inflammasome Pathway and Mitochondrial ROS
Research Article

Baicalein Protects H9c2 Cardiomyoblasts Against LPS-Induced Inflammatory Injury by Modulating the NF-κB/NLRP3 Inflammasome Pathway and Mitochondrial ROS

Yi Lu,
Zahra Zahid Piracha,
Umar Saeed,
Fangjun Luo*
PDFFinal Published
27
Apr
2026
Research Article

Folic Acid Ameliorates the Chronic Constriction Injury of Sciatic Nerve -Induced Memory Impairments in Rats

Arunachalam MuthuramanORCID*,
Mohamed Meeran Sheik DavoothORCID,
Seema MehdiORCID**,
Nallupillai ParamakrishnanORCID,
Satbir KaurORCID,
Thiagharajan Venkata Rathina KumarORCID
,et al.
PDFFinal Published
26
Apr
2026
Antimalarial Activity of Methoxylated Flavonoid Fraction (Cirsimaritin-Dominated) from Artemisia kopetdaghensis in Plasmodium berghei-Infected Mice with in silico Analysis
Research Article

Antimalarial Activity of Methoxylated Flavonoid Fraction (Cirsimaritin-Dominated) from Artemisia kopetdaghensis in Plasmodium berghei-Infected Mice with in silico Analysis

Roya Amirian,
Seyed Hossein Hejazi,
Naser Ghoddosi,
Hamed Fouladseresht,
Morteza Sadeghi,
Seyed Mahmoud MousaviORCID
,et al.
PDFFinal Published
25
Apr
2026
Promising Therapeutic Potential of miR-220-3p Mimic Against Murine Trimethyltin Hippocampal Injury
Research Article

Promising Therapeutic Potential of miR-220-3p Mimic Against Murine Trimethyltin Hippocampal Injury

Roya Khosh Ravesh,
Vahid Khodashenas,
Mina Goudarzi,
Leila Mohammadi,
Tourandokht Baluchnejadmojarad*,
Mehrdad RoghaniORCID
PDFFinal Published
20
Apr
2026
Anti-inflammation and Anti-insulin Resistance of a Compound from Vietnamese Clerodendrum chinense Leaves
Research Article

Anti-inflammation and Anti-insulin Resistance of a Compound from Vietnamese Clerodendrum chinense Leaves

Thu Thi Xuan Nguyen,
Cuong Trinh Tat*
PDFFinal Published
20
Apr
2026
Anticancer Effects of Ziziphus jujuba in Human Breast Carcinoma: An Integrated Study of Network Pharmacology, Molecular Docking and Dynamics Simulations and in-vitro Experimental Validation
Research Article

Anticancer Effects of Ziziphus jujuba in Human Breast Carcinoma: An Integrated Study of Network Pharmacology, Molecular Docking and Dynamics Simulations and in-vitro Experimental Validation

Jinxin Guo,
Jing ShenORCID*
PDFUncorrected Proof
18
Apr
2026
Probiotics Ameliorate Atrial Fibrillation-Associated Biomarkers and Inflammation in Rats via Modulation of the Gut Microbiota and NLRP3 Inflammasome Pathway
Research Article

Probiotics Ameliorate Atrial Fibrillation-Associated Biomarkers and Inflammation in Rats via Modulation of the Gut Microbiota and NLRP3 Inflammasome Pathway

Yeran Zhu,
Long Bai,
Ruibin Li,
Yichen Li,
Hongxia Hou,
Jidong ZhangORCID*
PDFFinal Published
18
Apr
2026
Astragalus Polysaccharide Suppresses Inflammation and Promotes Apoptosis in Hypertrophic Scars by Suppressing OGT-Mediated Nrf2 O-GlcNAcylation
Research Article

Astragalus Polysaccharide Suppresses Inflammation and Promotes Apoptosis in Hypertrophic Scars by Suppressing OGT-Mediated Nrf2 O-GlcNAcylation

Hengfei Wang*
PDFFinal Published
15
Apr
2026
miR-146a-Enriched Extracellular Vesicles Attenuate Neuroinflammation and Promote Recovery After Ischemic Stroke
Research Article

miR-146a-Enriched Extracellular Vesicles Attenuate Neuroinflammation and Promote Recovery After Ischemic Stroke

Nana Hao,
FuHua Gong*
PDFFinal Published
15
Apr
2026
Wedelolactone Inhibits Hepatitis B Virus Replication by Modulating NF-κB and Nrf2/HO-1 Signaling: An in-vitro Huh7 1.3-mer HBV Plasmid Model
Research Article

Wedelolactone Inhibits Hepatitis B Virus Replication by Modulating NF-κB and Nrf2/HO-1 Signaling: An in-vitro Huh7 1.3-mer HBV Plasmid Model

Bin Wang,
Xuehui Bu,
Umar Saeed,
Zahra Zahid Piracha,
Di Xiao*
PDFFinal Published
14
Apr
2026
Gamabufotalin Suppresses Colorectal Cancer Growth via Oxidative Stress-Induced Apoptosis and DNA Synthesis Inhibition
Research Article

Gamabufotalin Suppresses Colorectal Cancer Growth via Oxidative Stress-Induced Apoptosis and DNA Synthesis Inhibition

Hui Nie,
Anfang Cui,
Zhicheng Sun,
Zhaoyang Li,
Jianhua GuoORCID,
Shuhao Fan
,et al.
PDFFinal Published
12
Apr
2026
Hepatoprotective and Antioxidant Activities of a Medicine-Food Homology Formula and Its Lactiplantibacillus plantarum-Fermented Product Against Acetaminophen-Induced Oxidative Stress in HepG2 Cells
Research Article

Hepatoprotective and Antioxidant Activities of a Medicine-Food Homology Formula and Its Lactiplantibacillus plantarum-Fermented Product Against Acetaminophen-Induced Oxidative Stress in HepG2 Cells

Ching-Hui Hu,
Simon Anthony Kayombo,
Chih Min YangORCID*
PDFFinal Published
11
Apr
2026
Phytochemicals Characterization and Antidiabetic Efficacy of Muntingia calabura L. Leaves Extract: In vitro and in vivo Studies
Research Article

Phytochemicals Characterization and Antidiabetic Efficacy of Muntingia calabura L. Leaves Extract: In vitro and in vivo Studies

Raden Maya FebriyantiORCID*,
Mayra Fauzia,
Nurqisthi Iqlimia,
Aalbrecht Alby IrawanORCID,
Dwintha Lestari,
Yoppi IskandarORCID
,et al.
PDFFinal Published
18
Mar
2026
Establishing 18F-PSMA-1007 Production in Armenia: Radiosynthesis and Comprehensive Quality Control
Research Article

Establishing 18F-PSMA-1007 Production in Armenia: Radiosynthesis and Comprehensive Quality Control

Hayk PetrosyanORCID*,
Marine MnatsakanyanORCID,
Isabella KarapetyanORCID,
Andranik ManukyanORCID,
Gurgen ElbakyanORCID,
Davit ArshakyanORCID
,et al.
PDFFinal Published
2
Mar
2026
Hydroalcoholic Extract of Ferula aucheri Shows Anti-depressant Effect Against Lipopolysaccharide-Induced Depression in Mice: Involvement of NF-κB and TLR4 Signaling Pathway
Research Article

Hydroalcoholic Extract of Ferula aucheri Shows Anti-depressant Effect Against Lipopolysaccharide-Induced Depression in Mice: Involvement of NF-κB and TLR4 Signaling Pathway

Mohammad Mehdi GravandiORCID,
Maryam Naseri,
Nasim Jamshidi,
Samira ShirooieORCID*
PDFFinal Published
21
Feb
2026
Vitamin P Significantly Inhibits the Expression of Ki67 and VEGF and Promotes the Apoptosis of Colorectal Cancer Cells
Research Article

Vitamin P Significantly Inhibits the Expression of Ki67 and VEGF and Promotes the Apoptosis of Colorectal Cancer Cells

Xin Zhao,
Shang Guo,
Rongwei Shen,
Wei Zhang,
Yamin Zhang*
PDFFinal Published
18
Feb
2026
Quercetin Induces Macrophage Polarization through PI3K-AKT Pathway in Atherosclerosis: Network Pharmacology, Molecule Docking and in vitro Analysis
Research Article

Quercetin Induces Macrophage Polarization through PI3K-AKT Pathway in Atherosclerosis: Network Pharmacology, Molecule Docking and in vitro Analysis

Li Wang,
Yifan Han,
Yuyu Lei,
Jingfeng Liu*,
Jiajun Yu,
Guiyu Li
PDFFinal Published
15
Feb
2026
Innovative Peptide Therapeutics for SARS-CoV-2: Design, Docking, and Functional Analysis
Research Article

Innovative Peptide Therapeutics for SARS-CoV-2: Design, Docking, and Functional Analysis

Samaneh Karimkhanilouei,
Saeid GhorbianORCID*,
Sanaz Mahmazi,
Changiz Ahmadizadeh,
Keivan Nedaei
PDFFinal Published
15
Feb
2026
Affordability Analysis of Selected Medicines in Iran: A National Cross-sectional Survey Using World Health Organization Out-of-Pocket Methodology
Research Article

Affordability Analysis of Selected Medicines in Iran: A National Cross-sectional Survey Using World Health Organization Out-of-Pocket Methodology

Fatemeh SoleymaniORCID,
Amirhossein AbdiORCID,
Alireza Mirzaei,
Mohammad Mahdi Raeis ZadehORCID,
Ali Zeinalkhani,
Behzad FatemiORCID*
PDFFinal Published
14
Feb
2026
Pharmaceutical Utilization Review: A Five-Year Time Trend Analysis of the Pharmaceutical Market in Iran
Research Article

Pharmaceutical Utilization Review: A Five-Year Time Trend Analysis of the Pharmaceutical Market in Iran

Mohammadamir NematiORCID,
Behzad FatemiORCID,
Fatemeh SoleymaniORCID*,
Meysam SeyedifarORCID,
Donya ZaliORCID,
Zahra ShahaliORCID
,et al.
PDFFinal Published
12
Feb
2026
Acylglycerol Kinase 2-mediated Inhibition of Sirtuin 2 Restores AMPK/AKT/mTOR Signaling Balance in Podocytes: A Pharmacological Strategy for Diabetic Nephropathy
Research Article

Acylglycerol Kinase 2-mediated Inhibition of Sirtuin 2 Restores AMPK/AKT/mTOR Signaling Balance in Podocytes: A Pharmacological Strategy for Diabetic Nephropathy

Zahra Zahid Piracha,
Umar Saeed*,
Syed Muhammad Aun Raza,
Zia Ashraf,
Bazaid Muhammad,
Mehedi Tubaishi Rubab
,et al.
PDFFinal Published
12
Feb
2026
Research Article

Determining Modern Marketing Mix Elements and Their Measurement Indicators for Selling Cosmetic and Health Products in Iranian Pharmacies: A Descriptive-Analytical Cross-sectional Study

Reza Yaghoubi Nezhad,
Majid AnnabiORCID*,
Amin Akbari,
Yasaman Bastami,
Mahdi Maleki Zadeh
PDFFinal Published
11
Feb
2026
Comparison of the Effects of Sevoflurane and Isoflurane During Liver Transplant Surgery on the Short-Term Cardiac, Hepatic, and Renal Outcome: A Randomized Clinical Trial
Research Article

Comparison of the Effects of Sevoflurane and Isoflurane During Liver Transplant Surgery on the Short-Term Cardiac, Hepatic, and Renal Outcome: A Randomized Clinical Trial

Mohammadreza MoshariORCID,
Sadaf TaheryORCID,
Mastaneh Dahi TaleghaniORCID,
Shide DabirORCID,
Maryam VosoughianORCID,
Soudeh TabashiORCID
,et al.
PDFFinal Published
10
Feb
2026
Effect of Lemon Inhalation Aromatherapy on Postoperative Pain, Nausea and Vomiting, Delirium, and Inflammatory Markers After Coronary Artery Bypass Grafting: A Triple-Blind Randomized Trial
Research Article

Effect of Lemon Inhalation Aromatherapy on Postoperative Pain, Nausea and Vomiting, Delirium, and Inflammatory Markers After Coronary Artery Bypass Grafting: A Triple-Blind Randomized Trial

Siavash SangiORCID,
Seyed Mohammadreza Amouzegar Zavareh*,
Hedayat Sahraei,
Mojtaba Sepandi,
Alireza Moradi
PDFFinal Published
9
Feb
2026
Comparative Study on the Effects of Ginseng and Green Tea Extracts on Selected Lipid Metabolism Markers in Adipocyte
Research Article

Comparative Study on the Effects of Ginseng and Green Tea Extracts on Selected Lipid Metabolism Markers in Adipocyte

Mandana Salehi,
Kahin ShahanipourORCID*,
Ramesh Monajemi,
Parisa Mohamadynejad
PDFFinal Published
8
Feb
2026
KIM-1 as an Early Diagnostic Biomarker of Cisplatin-Induced Acute Kidney Injury
Research Article

KIM-1 as an Early Diagnostic Biomarker of Cisplatin-Induced Acute Kidney Injury

Ai-Hui Jin,
Yan-Jie Zheng,
Chen-Long Xu,
Li Zhou,
Hao Wang*,
Wen-Juan Wang**
PDFFinal Published
8
Feb
2026
Research Article

Impact of Mild Traumatic Brain Injury (mTBI) on CYP2D6 Activity and the Restorative Effects of Melatonin and Vitamin C Supplementation

Kaveh Berenjian,
Ziba Gholipour,
Mohammadreza Khoshayand,
Mohammad Sharifzadeh,
Mohammadreza Rouini,
Yalda Hosseinzadeh Ardakani*
PDFFinal Published
1
Feb
2026
Dual TYK2/JAK1 Inhibition by Brepocitinib Reprograms Synoviocyte Pathobiology: Mechanistic Insights Into Targeted Therapy for Rheumatoid Arthritis
Research Article

Dual TYK2/JAK1 Inhibition by Brepocitinib Reprograms Synoviocyte Pathobiology: Mechanistic Insights Into Targeted Therapy for Rheumatoid Arthritis

Umar Saeed*,
Zahra Zahid Piracha,
Andromeda M. Nauli,
Surya M. Nauli**
PDFFinal Published