The Effect of Oral Administration of L-Tyrosine, Folic acid and Pyridoxine on Perphenazine Induced Catatonia in Rat
Authors
Abstract
L-tyrosine, B6 and folic acid are involved in biosynthesis of DOPA and consequently dopamine. The aim of this study was to investigate the antiparkinsonian effect of these agents in perphenazine-induced catatonia in rats. Murprogo method or scored muscular rigidity, which is induced by a phenothiazine, was used to evaluate the antiparkinsonian effect of these agents. A significant decrease in muscular rigidity was observed in groups that received L-tyrosine. However, groups which had received vitamin(s) only showed no significant decrease in muscular rigidity as compared with the control group. On the other hand, the group receiving folic acid plus L-tyrosine showed a lower degree of muscular rigidity in comparison with the other groups.
In conclusion, L-tyrosine has been found to be effective in improving perphenazine-induced muscular rigidity. Furthermore, when used in combination with folic acid, L-tyrosine could be found advantageous in the early stages of Parkinson's disease.
Copyright
© 2022, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
THE EFFECT OF L-TYROSINE, VITAMINS E AND C ON PERPHENAZINE-INDUCED CATATONIA IN RAT
Arzi A, Hemmati A, Ghobishavi S, Arzi L. THE EFFECT OF L-TYROSINE, VITAMINS E AND C ON PERPHENAZINE-INDUCED CATATONIA IN RAT. Jundishapur J Nat Pharm Prod. 2007;2(1):. doi:
THE EFFECT OF SELEGILINE AND BROMOCRIPTINE IN THE PROPHYLAXIS OF PERPHENAZINE-INDUCED PSEUDOPARKINSONISM IN RAT: A COMPARATIVE STUDY
Arzi A, Hemmati A, Pipelzadeh M, Latifi S, Ramesh F. THE EFFECT OF SELEGILINE AND BROMOCRIPTINE IN THE PROPHYLAXIS OF PERPHENAZINE-INDUCED PSEUDOPARKINSONISM IN RAT: A COMPARATIVE STUDY. Jundishapur J Nat Pharm Prod. 2006;1(1):. doi:
Behavioral Outcomes and Histopathological Alterations in a Rotenone-induced Parkinson’s Disease Model: A Comparative Study of L-Dopa and Apomorphine
Modarres Mousavi SM, Alipour F, Lotfollahzadeh S, Mousazadeh F, Hosseini H, et al. Behavioral Outcomes and Histopathological Alterations in a Rotenone-induced Parkinson’s Disease Model: A Comparative Study of L-Dopa and Apomorphine. J Rep Pharm Sci. 2025;13(1):e162472. doi: https://doi.org/10.5812/jrps-162472
Effect of potassium channel blocker 4-aminopyridine pretreatment on the 6-OHDA-induced Parkinson's disease in rats
Sofiabadi M, haghdoost-yazdi H, Mahmudi M, Pri H, Dargahi T, et al. Effect of potassium channel blocker 4-aminopyridine pretreatment on the 6-OHDA-induced Parkinson's disease in rats. J Inflamm Dis. 2024;19(2):e155895. doi:
Effect of potassium channel blocker of Tetraethylammonium pretreatment on prevention of the 6-OHDA-induced chronic Parkinson\'s disease in rats
Haghdoost-Yazdi H, sehat bakhsh S, Sofiabadi M, Dargahi T, Yaghubidust M, et al. Effect of potassium channel blocker of Tetraethylammonium pretreatment on prevention of the 6-OHDA-induced chronic Parkinson\'s disease in rats. J Inflamm Dis. 2024;20(2):e155962. doi:
- Scopus by DOI: 1
Last Update: 1 month ago
- Scopus by Title: 1
Last Update: 1 month ago
- Scopus by Title (Ref): 0
Last Update: 1 month ago
- CrossRef: 0
Last Update: 3 days ago