The Enhancing Effect of Sodium Glycocholate and Sodium Salicylate on Rats     Gastro-intestinal Permeability to Insulin

Eskandar Moghimipour; Amir Jalali; Seyyed Abolghassem Sajjadi Tabassi; Raimar Löbenberg

doi:10.22037/ijpr.2010.581

IJ Pharmaceutical Research

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https://doi.org/10.22037/ijpr.2010.581

The Enhancing Effect of Sodium Glycocholate and Sodium Salicylate on Rats Gastro-intestinal Permeability to Insulin

Author(s):

Eskandar Moghimipour

^1,*,

Amir Jalali²,

Seyyed Abolghassem Sajjadi Tabassi³,

Raimar Löbenberg⁴

1Department of Pharmaceutics, School of Pharmacy, Jondishapour University of Medical Sciences, Ahwaz, Iran

2Department of Pharmacologys, School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

3Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

4Faculty of Pharmacy and Pharmaceutical Science, Dentistry/Pharmacy Centre, University of Alberta, Edmonton, Alberta, Canada

IJ Pharmaceutical Research:Vol. 3, issue 2; 87-91

Published online:Nov 20, 2010

Article type:Research Article

Received:Jan 01, 2004

Accepted:Jul 01, 2004

How to Cite:Eskandar MoghimipourAmir JalaliSeyyed Abolghassem Sajjadi TabassiRaimar LöbenbergThe Enhancing Effect of Sodium Glycocholate and Sodium Salicylate on Rats Gastro-intestinal Permeability to Insulin.Iran J Pharm Res.3(2):e128187.https://doi.org/10.22037/ijpr.2010.581.

Abstract

There have been numerous efforts to formulate insulin into an oral dosage form. The major problems involved with the oral administration of insulin are acidic and enzymatic decomposition by the gastric medium, and poor absorption in the small intestine due to its macromolecular structure.

This study attempted to test the enhancing ability of two absorption enhancers, sodium glycocholate (Na-GC) and sodium salicylate (Na-Sal), in different parts of rat's gastro-intestinal tract. The amount of insulin in each formulation was 0.6 iu/kg body weight. The concentration of enhancers (Na-Sal or Na-GC) in each formulation was 10 µg/ml. Formulations made of insulin and enhancers were prepared and injected directly to stomach, duodenum, jejunum and ileum of anesthetized rats through an abdominal incision. Blood samples were taken at 45 and 60 min intervals. The glucose concentration was determined by the o-toluidine method. Injections (IP) of insulin and normal saline were positive and negative controls, respectively.

The blood glucose concentrations showed a significant decrease (p<0.05) due to the injection of insulin into duodenum, while the effect noted in jejunum was insignificant (p>0.05). Also, there was no anti-hyperglycemic effect accompanied by formulations administered into the stomach and ileum. It could be concluded that insulin, if formulated in a protected form to prevent acidic and enzymatic decomposition, in combination with such enhancers may overcome hyperglycemia due to insulin deficiency.

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Author(s):

Eskandar Moghimipour:[PubMed][Scholar]
Amir Jalali:[PubMed][Scholar]
Seyyed Abolghassem Sajjadi Tabassi:[PubMed][Scholar]
Raimar Löbenberg:[PubMed][Scholar]