Effect of Hydroalcoholic Extract of Pycnocycla spinosa on Rat Isolated Bladder Contraction

Hassan Sadraei; Gholamreza Asghari; Atefah Arabzadeh

doi:10.22037/ijpr.2010.607

IJ Pharmaceutical Research

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https://doi.org/10.22037/ijpr.2010.607

Effect of Hydroalcoholic Extract of Pycnocycla spinosa on Rat Isolated Bladder Contraction

Author(s):

Hassan Sadraei^1,*,

Gholamreza Asghari²,

Atefah Arabzadeh¹

1Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

2Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

IJ Pharmaceutical Research:Vol. 3, issue 4; 237-241

Published online:Nov 20, 2010

Article type:Research Article

Received:Jun 01, 2004

Accepted:Oct 01, 2004

How to Cite:Hassan SadraeiGholamreza AsghariAtefah ArabzadehEffect of Hydroalcoholic Extract of Pycnocycla spinosa on Rat Isolated Bladder Contraction.Iran J Pharm Res.3(4):e128217.https://doi.org/10.22037/ijpr.2010.607.

Abstract

Hydroalcoholic extract of Pycnocycla spinosa is a relaxant of rat ileum and inhibits diarrhea in mice. As P. spinosa extract has spasmolytic activity on ileum, it could also affect other smooth muscles like bladder. Therefore, the aim of this study was to determine the effect of P. spinosa extract on rat bladder contraction.

In an in vitro study, the effects of P. spinosa extract, nifedipine and propantheline were tested on isolated rat bladder contractions induced by acetylcholine (ACh, 10 M) and KCl (80 mM).

P. spinosa extract, concentration-dependently, inhibited the bladder contractions induced by ACh with an IC50 of 265±28 µg/ml, and KCl with an IC50 of 518±86 µg/ml. The muscarinic cholinoceptor antagonist, propantheline, inhibited the response of ACh without affecting KCl response. Nifedipine, on the other hand, abolished the KCl response, while partially inhibiting the ACh contraction in rat bladder.

The antispasmodic effect of P. spinosa extract on bladder was observed at higher concentrations as compared to that of ileum. Therefore, it is unlikely that P. spinosa extract at anti-diarrheal doses affect the normal bladder emptying function.

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Author(s):

Hassan Sadraei:[PubMed][Scholar]
Gholamreza Asghari:[PubMed][Scholar]
Atefah Arabzadeh:[PubMed][Scholar]