Antioxidant, Antibacterial Activities and General Toxicity of Alnus glutinosa, Fraxinus excelsior and Papaver rhoeas

Patricia Middleton; Fiona Stewart; Salem Al-Qahtani; Paula Egan; Ciara O’Rourke; Aysha Abdulrahman; Maureen Byres; Moira Middleton; Yashodharan Kumarasamy; Mohammad Shoeb; Lutfun Nahar; Abbas Delazar; Satyajit Dey Sarker

doi:10.22037/ijpr.2010.620

IJ Pharmaceutical Research

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https://doi.org/10.22037/ijpr.2010.620

Antioxidant, Antibacterial Activities and General Toxicity of Alnus glutinosa, Fraxinus excelsior and Papaver rhoeas

Author(s):

Patricia Middleton¹,

Fiona Stewart¹,

Salem Al-Qahtani¹,

Paula Egan¹,

Ciara O’Rourke¹,

Aysha Abdulrahman¹,

Maureen Byres¹,

Moira Middleton¹,

Yashodharan Kumarasamy¹,

Mohammad Shoeb²,

Lutfun Nahar²,

Abbas Delazar³,

Satyajit Dey Sarker^4,*

1School of Pharmacy, The Robert Gordon University, Aberdeen, Scotland, UK

2School of Life Sciences, The Robert Gordon University, Aberdeen, Scotland, UK

3School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

4School of Biomedical Sciences, University of Ulster, Coleraine, Londonderry, Northern Ireland, UK

IJ Pharmaceutical Research:Vol. 4, issue 2; 81-86

Published online:Nov 20, 2010

Article type:Research Article

Received:May 20, 2004

Accepted:Feb 20, 2005

How to Cite:Patricia MiddletonFiona StewartSalem Al-QahtaniPaula EganCiara O’RourkeAysha AbdulrahmanMaureen ByresMoira MiddletonYashodharan KumarasamyMohammad ShoebLutfun NaharAbbas DelazarSatyajit Dey Sarkeret al.Antioxidant, Antibacterial Activities and General Toxicity of Alnus glutinosa, Fraxinus excelsior and Papaver rhoeas.Iran J Pharm Res.4(2):e128229.https://doi.org/10.22037/ijpr.2010.620.

Abstract

Alnus glutinosa, Fraxinus excelsior and Papaver rhoeas have long been used in folkloric medicine for the treatment of various ailments. As part of our continuing screening of plant extracts for activities, the extracts of A. glutinosa, F. excelsior and P. rhoeas have been screened for their antioxidant and antibacterial activities, as well as their general toxicity towards brine shrimps. Among the extracts, the methanol (MeOH) extract of F. excelsior displayed the highest level of antioxidant activity (RC₅₀=1.35x10^-2 mg/mL) and the dichloromethane (DCM) extract of P. rhoeas was the most toxic extract towards brine shrimps (LD₅₀=2.4x10^-2 mg/mL). The n-hexane and DCM extracts of F. excelsior and the MeOH extract of A. glutinosa were active (MIC values were within 1.25x10^-1 and 1.00 mg/mL) against all 8 bacterial species tested, including methicillin-resistant Staphylococcus aureus (MRSA).

Keywords

2

2-Diphenyl-1-picrylhydrazyl (DPPH)

Brine shrimp lethality assay

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Author(s):

Patricia Middleton:[PubMed][Scholar]
Fiona Stewart:[PubMed][Scholar]
Salem Al-Qahtani:[PubMed][Scholar]
Paula Egan:[PubMed][Scholar]
Ciara O’Rourke:[PubMed][Scholar]
Aysha Abdulrahman:[PubMed][Scholar]
Maureen Byres:[PubMed][Scholar]
Moira Middleton:[PubMed][Scholar]
Yashodharan Kumarasamy:[PubMed][Scholar]
Mohammad Shoeb:[PubMed][Scholar]
Lutfun Nahar:[PubMed][Scholar]
Abbas Delazar:[PubMed][Scholar]
Satyajit Dey Sarker:[PubMed][Scholar]