In vitro Anti-epimastigote Activity of some Iranian Medicinal Plants

authors:

avatar Elham Barari 1 , * , avatar Ahmad Reza Gohari 1 , avatar Fumiyuki Kiuchi 2 , avatar Gisho Honda 3

Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Tsukuba Medicinal Plant Research Station, National Institute of Health Sciences, Ministry of Health, Labour and Welfare, Tsukuba, Ibaraki, Japan
Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
Iranian Journal of Pharmaceutical Research: Vol.4, issue 2; 101-103
published online: November 20, 2010
article type: Research Article
received: June 20, 2004
accepted: February 20, 2005
DOI: https://doi.org/10.22037/ijpr.2010.623

how to cite: Barari E, Gohari A R, Kiuchi F, Honda G. In vitro Anti-epimastigote Activity of some Iranian Medicinal Plants. Iran J Pharm Res. 2005;4(2):e128232. https://doi.org/10.22037/ijpr.2010.623.

Abstract

Some medicinal plants are a potential source of new drugs, in order to improve the treatment of Chagas disease whose treatment is still a challenge. In this study, the in vitro anti-epimastigote activity of certain fractions of Achillea biebersteinii, A. millefolium, Satureja mutica and S. macrantha was evaluated. Diethyl ether fractions of Achillea species and acetone fractions of Satureja species were the most active fractions (MLC=12.5 µg/ml) against the epimastigotes of Trypanosoma cruzi, the ethiological agent causing Chagas disease. The trypanocidal activity seems to be decreased by fractionation, using MeOH and water as the solvents. The results obtained from assay revealed that Achillea and Satureja species could be a source of active trypanocidal compounds.