Derivative Spectrophotometry for Simultaneous Analysis of Chlorpheniramine Maleate, Phenylephrine HCl, and Phenylpropanolamine HCl in Ternary Mixtures and Pharmaceutical Dosage Forms

Maryam Kazemipour; Mehdi Ansari

doi:10.22037/ijpr.2010.630

IJ Pharmaceutical Research

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https://doi.org/10.22037/ijpr.2010.630

Derivative Spectrophotometry for Simultaneous Analysis of Chlorpheniramine Maleate, Phenylephrine HCl, and Phenylpropanolamine HCl in Ternary Mixtures and Pharmaceutical Dosage Forms

Author(s):

Maryam Kazemipour¹,

Mehdi Ansari^2,*

1Department of Chemistry, Faculty of Sciences, Kerman Azad University, Kerman, Iran

2Department of Pharmaceutics, Faculty of Pharmacy, Kerman Medical Sciences University, Kerman, Iran

IJ Pharmaceutical Research:Vol. 4, issue 3; 147-153

Published online:Nov 20, 2010

Article type:Research Article

Received:Nov 20, 2004

Accepted:Mar 20, 2005

How to Cite:Maryam KazemipourMehdi AnsariDerivative Spectrophotometry for Simultaneous Analysis of Chlorpheniramine Maleate, Phenylephrine HCl, and Phenylpropanolamine HCl in Ternary Mixtures and Pharmaceutical Dosage Forms.Iran J Pharm Res.4(3):e128238.https://doi.org/10.22037/ijpr.2010.630.

Abstract

In this study, different derivative spectrophotometric methods are proposed for the simultaneous determination of chlorpheniramine maleate (CP), phenylephrine HCl (PE) and phenylpropanolamine HCl (PP) in their ternary mixtures and in pharmaceutical dosage forms. Spectra of single component and ternary mixtures of various concentrations and combinations from zero- to fourth-derivation were obtained. Also the spectra of the excipients including lactose, starch, and microcrystalline cellulose were obtained to study the possible interference from matrices. Zero-crossing derivative spectrophotometry based on recording the second-derivative curve for PE at 286.5 nm and fourth-derivative curve for PP at 220 nm were used for determining each component. Third component, CP, was determined by measuring absolute amplitudes at 265.8, 262.2, 269.5, and 273.8 nm in its second derivative spectra. Results showed that the matrices have no interferences. The calibration curves were linear in the range of 1-8 µg/ml for PE; 5-30 µg/ml for PP; and 2-8 µg/ml for CP. The limits of detection were 0.2 µg/ml for PE, 0.1 µg/ml for PP, and 0.3 µg/ml for CP. The mean percentage recoveries obtained for different synthetic mixtures by using this method were 95.3% with coefficient of variation of 4.3% for PE, 101.5% with coefficient of variation of 1.4% for PP, and 99.4% with coefficient of variation of 1.5% for CP. This method has been applied successfully for the determination of PE and PP in its combination with CP in Antihistamine Decongestant tablets with a high percentage of recovery, good accuracy and precision.

Keywords

Chlorpheniramine

Phenylpropanolamine

Phenylephrine

Derivative spectrophotometry

Antihistamine Decongestant

Tablet

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Author(s):

Maryam Kazemipour:[PubMed][Scholar]
Mehdi Ansari:[PubMed][Scholar]