Determination of Residual Methylmethacrylate Monomerin Denture Base Resins by Gas Chromatography

Khosrou Abdi; Ali Mandegary; Mohsen Amini; Mozhgan Bagheri; Farideh Gerami-Panah

doi:10.22037/ijpr.2010.641

IJ Pharmaceutical Research

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https://doi.org/10.22037/ijpr.2010.641

Determination of Residual Methylmethacrylate Monomerin Denture Base Resins by Gas Chromatography

Author(s):

Khosrou Abdi^1,*,

Ali Mandegary^{2, 3},

Mohsen Amini¹,

Mozhgan Bagheri¹,

Farideh Gerami-Panah⁴

1Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

2Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

3Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran

4Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran

IJ Pharmaceutical Research:Vol. 4, issue 4; 227-232

Published online:Nov 20, 2010

Article type:Research Article

Received:Nov 20, 2004

Accepted:Feb 20, 2005

How to Cite:Khosrou AbdiAli MandegaryMohsen AminiMozhgan BagheriFarideh Gerami-PanahDetermination of Residual Methylmethacrylate Monomerin Denture Base Resins by Gas Chromatography.Iran J Pharm Res.4(4):e128249.https://doi.org/10.22037/ijpr.2010.641.

Abstract

Acrylic base resins are widely used in orthopedics and dental surgery. It is generally accepted that due to the incomplete conversion of methyl methacrylate (MMA) monomer to the polymer form during polymerization of the resin, some MMA monomers remain in the hardened material. MMA monomer has been reported to cause abnormalities or lesions in several organs of animals. Study of the literatures showed that there are no perfect and valid methods for analysis of MMA. The aim of this study was to develop a simple and valid method for determination of MMA residual monomer in the denture base resins.

We have developed and validated an analytical procedure employing gas chromatography with flame ionization detector (GC-FID), with temperature programming, and a close analogue internal standard for fast and repeatable analysis of MMA residual monomer contents in denture base polymers. For quantification of monomer, two calibration curves were used by two different methods of solution preparation and they were compared to each other. The assay was linear over the range of 0.03-0.6 mg/ml MMA with correlation coefficients (r²) of greater than 0.99. Accuracy, intra-day (Error<9.1%) and inter-day (Error<6.6%) , precision (RSD<5.5% and RSD<6.5%, respectively) were in acceptable values over the examined concentration range. Limit of detection (LOD) and limit of Quantification (LOQ) for MMA were 0.01 and 0.02 mg/ml, respectively. In conclusion, the proposed method was a simple and fast assay for MMA residual monomer in denture base resins.

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Author(s):

Khosrou Abdi:[PubMed][Scholar]
Ali Mandegary:[PubMed][Scholar]
Mohsen Amini:[PubMed][Scholar]
Mozhgan Bagheri:[PubMed][Scholar]
Farideh Gerami-Panah:[PubMed][Scholar]