The Effects of Acetaminophen  on Human Serum Albumin (HSA)

Mostafa Rezaei Tavirani; Seyed Hassan Moghaddamnia; Bijan Ranjbar; Said Namaki; Parisa Zolfaghari

doi:10.22037/ijpr.2010.643

IJ Pharmaceutical Research

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https://doi.org/10.22037/ijpr.2010.643

The Effects of Acetaminophen on Human Serum Albumin (HSA)

Author(s):

Mostafa Rezaei Tavirani

^1,*,

Seyed Hassan Moghaddamnia²,

Bijan Ranjbar³,

Said Namaki²,

Parisa Zolfaghari⁴

1Faculty of Medicine, Medical University of Ilam, Ilam, Iran

2The Faculty of Paramedical Sciences, Shaheed Beheshti University of Medical Sciences and Health Services, Tehran, Iran

3Department of Biophysics, Faculty of Science, Tarbiat Moddares University, Tehran, Iran

4Center of Science and Researches, Islamic Azad University, Tehran, Iran

IJ Pharmaceutical Research:Vol. 4, issue 4; 239-244

Published online:Nov 20, 2010

Article type:Research Article

Received:May 20, 2005

Accepted:Oct 20, 2005

How to Cite:Mostafa Rezaei TaviraniSeyed Hassan MoghaddamniaBijan RanjbarSaid NamakiParisa ZolfaghariThe Effects of Acetaminophen on Human Serum Albumin (HSA).Iran J Pharm Res.4(4):e128251.https://doi.org/10.22037/ijpr.2010.643.

Abstract

Thermal conformational changes in human serum albumin (HSA) in present with a 10 mM phosphate buffer, at pH=7 have been investigated via circular dichroism (CD) and UV spectroscopic methods. The results indicate that temperature in a range of 25°C to 55°C could induce a reversible conformational change in the structure of HSA. The HSA phase transition corresponds to the physiological and pathological conditions of the body, especially fever. The conformational change observed in HSA is accompanied by a mild conversion of its secondary structures. Acetaminophen is a papular pain killer, and HSA is used as a drug carrier. Hence, acetaminophen could it interact with HSA. The study of HSA – acetaminophen interaction reveals the effects of acetaminophen on HSA structure, preventing it’s phase transition. HSA – acetaminophen interaction leads to the stabilization of HAS. This interaction is accompanied with 8 kJ/mol of free energy change. The structural changes within HSA due to it’s interaction with acetaminophen could be considered as a drug side effect and it may affect the protein functions.

Keywords

Human serum albumin

Conformation

Temperature

Circular dichroism (CD)

Acetaminophen

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Author(s):

Mostafa Rezaei Tavirani:[PubMed][Scholar]
Seyed Hassan Moghaddamnia:[PubMed][Scholar]
Bijan Ranjbar:[PubMed][Scholar]
Said Namaki:[PubMed][Scholar]
Parisa Zolfaghari:[PubMed][Scholar]