The Involvement of L-Type Voltage-Operated Calcium Channels in the Vascular Effect of Quercetin in Male Rats

authors:

avatar Mehrdad Roghani 1 , * , avatar Tourandokht Baluchnejadmojarad 2 , avatar Farshad Roghani Dehkordi 3

Department of Physiology, School of Medicine, Shahed University and Medicinal Plant Research Center, Tehran, Iran
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Department of Cardiology and Internal Medicine, School of Medicine, Shahrekord University of Medical Sciences, Tehran, Iran
Iranian Journal of Pharmaceutical Research: Vol.5, issue 3; 199-202
published online: November 20, 2010
article type: Research Article
received: October 21, 2004
accepted: November 21, 2005
DOI: https://doi.org/10.22037/ijpr.2010.675

how to cite: Roghani M, Baluchnejadmojarad T, Roghani Dehkordi F. The Involvement of L-Type Voltage-Operated Calcium Channels in the Vascular Effect of Quercetin in Male Rats. Iran J Pharm Res. 2006;5(3):e128285. https://doi.org/10.22037/ijpr.2010.675.

Abstract

In this study, the possible involvement of L-type voltage-operated calcium channels in the vasorelaxant effect of the flavonoid quercetin was investigated, using the isolated aortic rings from normal male rats. Addition of quercetin (0.1 µM-1 mM) caused a significant dose-dependent relaxation of noradrenaline (NA)- and KCl-preconstricted rings and nifedipine attenuated this response, especially for noradrenaline (P<0.05). It is concluded that the flavonoid quercetin produces a potent relaxation of the rat aorta and blockade of voltage-operated calcium channels could attenuate this effect.