Effects of Carbon Sources on Growth and Production of Antifungal Agents by Gymnopilus Spectabilis

authors:

avatar Hossein Vahidi 1 , * , avatar Faraz Mojab 1 , avatar Nasim Taghavi 1

Department of Pharmacognosy, Shaheed Beheshti Medical University, Tehran, Iran
Iranian Journal of Pharmaceutical Research: Vol.5, issue 3; 219-222
published online: November 20, 2010
article type: Research Article
received: January 21, 2006
accepted: June 21, 2006
DOI: https://doi.org/10.22037/ijpr.2010.679

how to cite: Vahidi H, Mojab F, Taghavi N. Effects of Carbon Sources on Growth and Production of Antifungal Agents by Gymnopilus Spectabilis. Iran J Pharm Res. 2006;5(3):e128289. https://doi.org/10.22037/ijpr.2010.679.

Abstract

Effects of different carbon sources on growth and production of antifungal agent(s) by Gymnopilus spectabilis were investigated. Different carbon sources including; Glucose, fructose, lactose, maltose, manitol and sucrose at the concentration of 10 g/l and slow releasing carbon sources including malt extract and soluble starch at the concentration of 2g/l were used. Inhibition of spore germination of Aspergillus niger was used to test antifungal activity. The results showed that the highest activity (90% inhibition of spore germination) and biomass concentration (2.4 g/l) were obtained when glucose was used as carbon source. Other media with different carbon sources showed antifungal activity ranging from 30% to 70% inhibition of spore germination. Combination of glucose with malt extract as a slow releasing carbon source was also increased activity to 100% inhibition.