Morphine-Induced Place Preference: Interactions with Neurotransmitter Systems

Mohammad Reza Zarrindast; Ameneh Rezayof

doi:10.22037/ijpr.2010.693

IJ Pharmaceutical Research

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https://doi.org/10.22037/ijpr.2010.693

Morphine-Induced Place Preference: Interactions with Neurotransmitter Systems

Author(s):

Mohammad Reza Zarrindast^{1, 2, 3,*},

Ameneh Rezayof⁴

1Department of Pharmacology, School of Medicine and Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran

2Institute for Studies in Theoretical Physics and Mathematics, School of Cognitive Sciences, Tehran, Iran

3Institute for Cognitive Science Studies, Tehran, Iran

4School of Biology, University College of Sciences, University of Tehran, Tehran, Iran

IJ Pharmaceutical Research:Vol. 6, issue 1; 3-15

Published online:Nov 20, 2010

Article type:Review Article

Received:Oct 21, 2006

Accepted:Nov 21, 2006

How to Cite:Mohammad Reza ZarrindastAmeneh RezayofMorphine-Induced Place Preference: Interactions with Neurotransmitter Systems.Iran J Pharm Res.6(1):e128304.https://doi.org/10.22037/ijpr.2010.693.

Abstract

This review gives an overview of our recent findings and developments in research on brain mechanisms of morphine reward from studies using the place preference conditioning paradigm. Intracranial place conditioning methodology has become a valuable and firmly established and very widely used tool in behavioural pharmacology and drug reward mechanisms. Several studies have established that morphine induces a conditioned preference for the place in which it has been administered in rats. Transmitter systems that have been investigated with respect to their involvement in morphine reward mechanisms include dopamine, GABA, acetylcholine, adrenalin and nitric oxide, the motivational significance of which has been examined either directly, by using respective agonist or antagonist drugs. Although, considerable evidence suggested that the mesocorticolimbic DA system, which originates in the VTA and projects to the Nac, various limbic and cortical areas is a major neural substrate of the rewarding effects produced by morphine, but the role of other brain sites such as hippocampus and amygdala also exist. Overall, our intracranial place conditioning studies showed that there are a number of receptors, neuronal pathways and discrete central nervous system sites involved in the morphine reward mechanisms.

Keywords

Reward mechanisms

Neurotransmitters

Conditioned place preference

morphine

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Author(s):

Mohammad Reza Zarrindast:[PubMed][Scholar]
Ameneh Rezayof:[PubMed][Scholar]