The Different Mechanisms of Action Potential Propagation in the Heart

Somayeh Mahdavi; Mostafa Rezaei-Tavirani; Farzad Towhidkhah; Shahriar Gharibzadeh; Seyed Hasan Moghaddam niya

doi:10.22037/ijpr.2010.698

IJ Pharmaceutical Research

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https://doi.org/10.22037/ijpr.2010.698

The Different Mechanisms of Action Potential Propagation in the Heart

Author(s):

Somayeh Mahdavi¹,

Mostafa Rezaei-Tavirani^{2, 3},

Farzad Towhidkhah⁴,

Shahriar Gharibzadeh^5,*,

Seyed Hasan Moghaddam niya⁶

1Department of Cellular and Molecular Biology, Khatam University, Tehran, Iran

2Faculty of Medicine, Ilam Medical Sciences University, Ilam, Iran

3Asre Novin Institute of Research and Industrial Services, Tehran, Iran

4Biological Systems Modeling Laboratory, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran

5Neuromuscular Systems Laboratory, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran

6Faculty of Para-medical, Shaheed Beheshti Medical Science University, Tehran, Iran

IJ Pharmaceutical Research:Vol. 6, issue 1; 51-56

Published online:Nov 20, 2010

Article type:Research Article

Received:Mar 21, 2006

Accepted:Jul 21, 2006

How to Cite:Somayeh MahdaviMostafa Rezaei-TaviraniFarzad TowhidkhahShahriar GharibzadehSeyed Hasan Moghaddam niyaThe Different Mechanisms of Action Potential Propagation in the Heart.Iran J Pharm Res.6(1):e128309.https://doi.org/10.22037/ijpr.2010.698.

Abstract

It was thought previously that cardiac muscle gap junctions provide low-resistance connections between cells and permit the local-circuit current to flow. Some evidences show that myocardial cells may not require low-resistance connections for successful propagation of the action potential (AP). It seems that some other types of mechanisms must be involved in AP propagation.

In this article, we study the different suggested mechanisms of AP propagation. We have calculated different conduction routes and hypothesized novel viewpoints on the mechanisms of conduction in myocyte. It seems that electric field and gap junctions are the main routes for propagation of action potential, but they are affected in different phases of action potential. Gap junction has a dynamic behavior in each cardiac cycle, managing different routes of propagation in the diverse moments. Gap junctions could be open in phases 0, 1, 3 and 4 and close in phase 2 (plateau) of action potential. Whenever gap junction is open, conduction can be fulfilled rapidly by current flow and whenever it is closed, the electrical field will be the main route of propagation.

This view on AP propagation may be useful for better exploitation of drugs or designing new remedies in arrhythmias and diseases that cause diminished cardiac contractility such as cardiac failure.

Keywords

Gap junction

Sodium concentration

Potassium concentration

Action potential propagation

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Author(s):

Somayeh Mahdavi:[PubMed][Scholar]
Mostafa Rezaei-Tavirani:[PubMed][Scholar]
Farzad Towhidkhah:[PubMed][Scholar]
Shahriar Gharibzadeh:[PubMed][Scholar]
Seyed Hasan Moghaddam niya:[PubMed][Scholar]