Analgesic Efficacy of Interpleurally Administered Morphine and Fentanyl After Posterolateral Thoracotomy

1National Research Institute of Tuberculosis and Lung Disease, Dr. Masih Daneshvari Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

2Department of Biostatistics, School of Paramedical Sciences, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

3Department of Clinical Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

IJ Pharmaceutical Research:Vol. 6, issue 1; 57-63

Published online:Nov 20, 2010

Article type:Research Article

Received:Jul 21, 2006

Accepted:Nov 21, 2006

How to Cite:Shideh DabirTahereh ParsaBadiozaman RadpaySaviz PozhhanAli Akbar Khadem MaboudiMohammad Abbasi-nazariJamshid Salamzadehet al.Analgesic Efficacy of Interpleurally Administered Morphine and Fentanyl After Posterolateral Thoracotomy.Iran J Pharm Res.6(1):e128310.https://doi.org/10.22037/ijpr.2010.699.

Abstract

Pain control is a major concern in post-thoracotomy patients. The current prospective randomized double-blind study was designed to evaluate the analgesic effects of morphine and fentanyl given interpleurally after posterolateral thoracotomy. Thirty patients undergoing elective posterolateral thoracotomy in a teaching hospital in Tehran were divided into 3 groups with equal number of patients. Patients in group IPM, IPF₁ and IPF₂ received 0.1 mg/kg morphine sulfate, 5 µg/kg fentanyl and 2.5 µg/kg fentanyl in a total volume of 40 ml injected via an intrapleural catheter placed in the pleural space before the closure of chest. Subsequent doses of interpleural injections were administered at 4 and 8 h after operation. The intensity of pain was evaluated at rest and with coughing just before each interpleural injection and 30 min afterwards using a 10 point visual analogue scale (VAS). If patients needed additional analgesia, indomethacin suppository and intravenous morphine were given during the 20-h postoperative study period. In all of the 3 study groups VAS scores were significantly reduced 30 min after interpleural administration of the study solutions (p<0.05). However, inter-group comparisons revealed no significant differences for VSA scores, supplemental analgesic usage and systemic side effects. Briefly, interpleural morphine and fentanyl following thoracotomy produce equal analgesia without major side effects.

Keywords

Fentanyl

morphine

Interpleural analgesia

Pain

Thoracotomy

comments

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

CrossRef 0

Metrics

Get Permission (article level)

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Shideh Dabir:[PubMed][Scholar]
Tahereh Parsa:[PubMed][Scholar]
Badiozaman Radpay:[PubMed][Scholar]
Saviz Pozhhan:[PubMed][Scholar]
Ali Akbar Khadem Maboudi:[PubMed][Scholar]
Mohammad Abbasi-nazari:[PubMed][Scholar]
Jamshid Salamzadeh:[PubMed][Scholar]