Development and Characterization of Paracetamol Complexes with Hydroxypropyl-β-Cyclodextrin

authors:

avatar Sushma Talegaonkar 1 , * , avatar Azhar Yakoob Khan 1 , avatar Roop Kishan Khar 1 , avatar Farhan Jalees Ahmad 1 , avatar Zeenat I. Khan 1

Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, 110062, India
Iranian Journal of Pharmaceutical Research: Vol.6, issue 2; 95-99
published online: November 20, 2010
article type: Research Article
received: October 21, 2005
accepted: May 21, 2006
DOI: https://doi.org/10.22037/ijpr.2010.705

how to cite: Talegaonkar S, Khan A Y, Khar R K, Ahmad F J, Khan Z I. Development and Characterization of Paracetamol Complexes with Hydroxypropyl-β-Cyclodextrin. Iran J Pharm Res. 2007;6(2):e128316. https://doi.org/10.22037/ijpr.2010.705.

Abstract

Paracetamol is a sparingly soluble bitter tasting drug. It is widely used as an analgesic and antipyretic. Complexation of drug with different cyclodextrins (α, β and HP-β-CD) was attempted to improve solubility of Paracetamol. During the drug excipient interaction studies, α, β cyclodextrins elicited analytical interference and showed considerable absorbance at λmax (243.5 nm) of Paracetamol while the ones constituting of hydroxypropyl-beta-cyclodextrin (HP-β-CD) did not show any such interference. Therefore, the present study is concentrated on exploring HP-β-CD as complexing agent. Phase solubility studies showed that complexation of Paracetamol/HP-β-CD at molar ratio 1:1 and showed AL type solubility curve. Complexation was done by various methods like physical mixing, kneading and freeze drying and resulting drug complexes were characterized by Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared Spectroscopy (FTIR). The thermograms obtained showed an endothermic peak for Paracetamol, for physical mixture to some extent for kneaded mixture, but was completely eliminated for freeze dried product (Inclusion complex). Similar results were obtained during IR studies. Therefore, solid inclusion complex of paracetamol prepared by freeze drying method was found to be an ideal complex. The solubility of paracetamol, was significantly increased (six folds of normal solubility) by complexation with HP-β-CD.