Synthesis and Antidepressant Activity of N-Substituted Imidazole-5-Carboxamides in Forced Swimming Test Model

authors:

avatar Farzin Hadizadeh 1 , 2 , * , avatar Hossein Hosseinzadeh 1 , 2 , avatar Vahideh-Sadat Motamed-Shariaty 2 , avatar Mahmood Seifi 2 , avatar Shahab Kazemi 2

Department of Medicinal Chemistry, Pharmacy Faculty, Mashhad University of Medical Sciences, Mashhad, Iran
Biotechnology and Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Iranian Journal of Pharmaceutical Research: Vol.7, issue 1; 29-33
published online: November 20, 2010
article type: Research Article
received: April 01, 2007
accepted: November 01, 2007
DOI: https://doi.org/10.22037/ijpr.2010.741

how to cite: Hadizadeh F, Hosseinzadeh H, Motamed-Shariaty V, Seifi M, Kazemi S. Synthesis and Antidepressant Activity of N-Substituted Imidazole-5-Carboxamides in Forced Swimming Test Model. Iran J Pharm Res. 2008;7(1):e128567. https://doi.org/10.22037/ijpr.2010.741.

Abstract

Moclobemide is a selective and reversible monoamine oxidase-A inhibitor, which is used as an antidepressant. Three moclobemide analogues were synthesized by replacing moclobemide phenyl ring with substituted imidazoles. So, N-[(4-morpholinyl) ethyl)]-1-benzyl-2-(alkylthio)-1H-imidazole-5-carboxamides (7a-c) were synthesized and studied for the antidepressant activity using forced swimming test in mice. Analogues 7a-c were found to be more potent than moclobemide. Minimum effective doses for moclobemide and analogues 7a-c were found to be 20, 2.5, 1.25 and 2.5 mg/kg i.p. respectively.