Effects of Papaver rhoeas Extract on the Tolerance Development to Analgesic Effects of Morphine in Mice

Jamal Shams; Hedayat Sahraei; Zohreh Faghih-Monzavi; Seyed Hossein Salimi; Seyedeh Maedeh Fatemi; Ali Pourmatabbed; Hassan Ghoshooni; Mohammad Kamalinejad

doi:10.22037/ijpr.2010.757

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https://doi.org/10.22037/ijpr.2010.757

Effects of Papaver rhoeas Extract on the Tolerance Development to Analgesic Effects of Morphine in Mice

Author(s):

Jamal Shams^{1, 2},

Hedayat Sahraei^{3, 4,*},

Zohreh Faghih-Monzavi⁵,

Seyed Hossein Salimi⁶,

Seyedeh Maedeh Fatemi⁴,

Ali Pourmatabbed⁷,

Hassan Ghoshooni^{3, 8},

Mohammad Kamalinejad⁹

1Neuroscience Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

2Department of Psychiatry, School Of Medicine, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

3Department of Physiology and Biophysics, School of Medicine, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran

4Neurobiology Division, Applied Neuroscience Research Center (AN`RC), Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran

5Department of Biology, School of Science, North Tehran Branch, Islamic Azad University, Tehran, Iran

6Department of Psychology, School of Medicine, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran

7Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

8Chemical Injuries Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran

9Department of Pharmacognosy, School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

IJ Pharmaceutical Research:Vol. 7, issue 2; 141-147

Published online:Nov 20, 2010

Article type:Research Article

Received:Apr 01, 2007

Accepted:Jan 01, 2008

How to Cite:Shams J, Sahraei H, Faghih-Monzavi Z, Salimi SH, Fatemi SM, et al. Effects of Papaver rhoeas Extract on the Tolerance Development to Analgesic Effects of Morphine in Mice. Iran J Pharm Res. 2022;7(2):e128583. doi: https://doi.org/10.22037/ijpr.2010.757

Abstract

Previous studies have shown that the extract of Papaver rhoeas reduces morphine dependence, locomotor activity and reward. In present study, the effects of hydro-alcohol extract of Papaver Rhoeas on the tolerance to analgesic effects of morphine in mice have been investigated using tail flick method. Subcutaneous (s.c.) administration of morphine (1, 2, 5 and 10 mg/kg) induced analgesia. However, intrapretoneal administration of the hydro-alcohol extract of Papaver rhoeas (25, 50 and 100 mg/kg) had not an effects on analgesia. Reduction of analgesic in mice pretreated with morphine (50 mg/kg, twice daily; for 3 days), alone, indicated that tolerance has been developed. Hydro-alcohol extract of Papaver rhoeas (25, 50 and 100 mg/kg, i.p.) administration, 30 min before each of three daily doses of morphine, attenuated the morphine tolerance dose-independently,indicating that administration of the extract reduces morphine tolerance in mice.

Keywords

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Author(s):

Jamal Shams:[PubMed][Scholar]
Hedayat Sahraei:[PubMed][Scholar]
Zohreh Faghih-Monzavi:[PubMed][Scholar]
Seyed Hossein Salimi:[PubMed][Scholar]
Seyedeh Maedeh Fatemi:[PubMed][Scholar]
Ali Pourmatabbed:[PubMed][Scholar]
Hassan Ghoshooni:[PubMed][Scholar]
Mohammad Kamalinejad:[PubMed][Scholar]

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Effects of Papaver rhoeas Extract on the Tolerance Development to Analgesic Effects of Morphine in Mice

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