Effects of Papaver rhoeas Extract on the Tolerance Development to Analgesic Effects of Morphine in Mice

authors:

avatar Jamal Shams 1 , 2 , avatar Hedayat Sahraei 3 , 4 , * , avatar Zohreh Faghih-Monzavi 5 , avatar Seyed Hossein Salimi 6 , avatar Seyedeh Maedeh Fatemi 4 , avatar Ali Pourmatabbed 7 , avatar Hassan Ghoshooni 3 , 8 , avatar Mohammad Kamalinejad 9

Neuroscience Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
Department of Psychiatry, School Of Medicine, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
Department of Physiology and Biophysics, School of Medicine, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran
Neurobiology Division, Applied Neuroscience Research Center (AN`RC), Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran
Department of Biology, School of Science, North Tehran Branch, Islamic Azad University, Tehran, Iran
Department of Psychology, School of Medicine, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran
Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Chemical Injuries Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran
Department of Pharmacognosy, School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

how to cite: Shams J, Sahraei H, Faghih-Monzavi Z, Salimi S H, Fatemi S M, et al. Effects of Papaver rhoeas Extract on the Tolerance Development to Analgesic Effects of Morphine in Mice. Iran J Pharm Res. 2008;7(2):e128583. https://doi.org/10.22037/ijpr.2010.757.

Abstract

Previous studies have shown that the extract of Papaver rhoeas reduces morphine dependence, locomotor activity and reward. In present study, the effects of hydro-alcohol extract of Papaver Rhoeas on the tolerance to analgesic effects of morphine in mice have been investigated using tail flick method. Subcutaneous (s.c.) administration of morphine (1, 2, 5 and 10 mg/kg) induced analgesia. However, intrapretoneal administration of the hydro-alcohol extract of Papaver rhoeas (25, 50 and 100 mg/kg) had not an effects on analgesia. Reduction of analgesic in mice pretreated with morphine (50 mg/kg, twice daily; for 3 days), alone, indicated that tolerance has been developed. Hydro-alcohol extract of Papaver rhoeas (25, 50 and 100 mg/kg, i.p.) administration, 30 min before each of three daily doses of morphine, attenuated the morphine tolerance dose-independently,indicating that administration of the extract reduces morphine tolerance in mice.