Betamethasone Can Significantly Decrease Level of Striatal Glutamate in Animal Model of Parkinson's Disease

authors:

avatar Mehdi Shafiee Ardestani 1 , * , avatar Hadi Fathi-Moghaddam 2

Department of Medicinal Chemistry and Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Department of Physiology and Physiology Research Center, Jondishapour University of Medical Sciences, Ahwaz, Iran
Iranian Journal of Pharmaceutical Research: Vol.7, issue 3; 229-232
published online: November 20, 2010
article type: Rapid Communication
received: November 01, 2007
accepted: May 01, 2008
DOI: https://doi.org/10.22037/ijpr.2010.770

how to cite: Shafiee Ardestani M, Fathi-Moghaddam H. Betamethasone Can Significantly Decrease Level of Striatal Glutamate in Animal Model of Parkinson's Disease. Iran J Pharm Res. 2008;7(3):e128607. https://doi.org/10.22037/ijpr.2010.770.

Abstract

In the present study, the effect of steroidal anti-inflammatory drug betamethasone (0.12, 0.24 mg/kg, i.p. acutely) on striatal glutamate level in Parkinsonian rats was studied using the microdialysis technique. Our results showed significant differences (p<0.05) in the level of striatal glutamate between treated and non-treated damaged rats.