Effect of Antituberculosis Regimen Containing Ethambutol on Serum magnesium Level in Pulmonary Tuberculosis Patients

Mohammad Abbasi Nazari; Farzad Kobarfard; Payam Tabarsi; Maryam Azimi; Jamshid Salamzadeh

doi:10.22037/ijpr.2010.785

IJ Pharmaceutical Research

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https://doi.org/10.22037/ijpr.2010.785

Effect of Antituberculosis Regimen Containing Ethambutol on Serum magnesium Level in Pulmonary Tuberculosis Patients

Author(s):

Mohammad Abbasi Nazari^{1, 2},

Farzad Kobarfard^{3, 4},

Payam Tabarsi⁵,

Maryam Azimi¹,

Jamshid Salamzadeh^{1, 4,*}

1Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University, M.C., Tehran, Iran

2Research Center for Gastrointestinal and Liver Diseases (RCGLD), Shahid Beheshti University, M.C., Tehran, Iran

3Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University, M.C., Tehran, Iran

4Pharmaceutical Sciences Research Center, Shahid Beheshti University, M.C., Tehran, Iran

5TB and Lung Disease Research Center (NRITLD), Masih Daneshvari Hospital, Tehran, Iran

IJ Pharmaceutical Research:Vol. 8, issue 1; 33-36

Published online:Nov 20, 2010

Article type:Research Article

Received:Jun 01, 2008

Accepted:Nov 01, 2008

How to Cite:Mohammad Abbasi NazariFarzad KobarfardPayam TabarsiMaryam AzimiJamshid SalamzadehEffect of Antituberculosis Regimen Containing Ethambutol on Serum magnesium Level in Pulmonary Tuberculosis Patients.Iran J Pharm Res.8(1):e128612.https://doi.org/10.22037/ijpr.2010.785.

Abstract

Magnesium is an essential metal that has important roles in physiological function of the body organs. Ethambutol is an oral antitubercular agent with chelating effects owing to its chemical structure. The aim of present study is to determine whether ethambutol usage can alter serum magnesium concentration in patients with pulmonary tuberculosis. Sixty patients with diagnosis of pulmonary tuberculosis were enrolled in the study. Blood samples were obtained before treatment from patients. Ten days after starting anti tuberculosis therapy, second blood samples were obtained. The amounts of serum magnesium were determined in all samples by spectrophotometric method. Statistical analysis showed that serum magnesium concentrations at baseline (0.61±0.08 mmol/l) and at day 10 (0.62±0.11 mmol/l) were not different. It is possible that ethambotol does not affect magnesium concentration in tuberculosis patients, however further studies about the other cationic trace elements are recommended.

Keywords

Patient

Pulmonary tuberculosis

Ethambutol

Magnesium

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Author(s):

Mohammad Abbasi Nazari:[PubMed][Scholar]
Farzad Kobarfard:[PubMed][Scholar]
Payam Tabarsi:[PubMed][Scholar]
Maryam Azimi:[PubMed][Scholar]
Jamshid Salamzadeh:[PubMed][Scholar]