The Effect of Aqueous Crocus sativus L. Extract on Intracerebroventricular Streptozotocin-induced Cognitive Deficits in Rat: a Behavioral Analysis

Mohsen Khalili; Mehrdad Roghani; Majid Ekhlasi

doi:10.22037/ijpr.2010.809

IJ Pharmaceutical Research

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https://doi.org/10.22037/ijpr.2010.809

The Effect of Aqueous Crocus sativus L. Extract on Intracerebroventricular Streptozotocin-induced Cognitive Deficits in Rat: a Behavioral Analysis

Author(s):

Mohsen Khalili^1,*,

Mehrdad Roghani¹,

Majid Ekhlasi²

1Department of Physiology, School of Medicine and Medicinal Plant and Neuroscience Research Center, Shahed University of Medical Sciences, Tehran, Iran

2Department of Physiology, School of Medicine, Shahed University, Tehran, Iran

IJ Pharmaceutical Research:Vol. 8, issue 3; 185-191

Published online:Nov 20, 2010

Article type:Research Article

Received:Jun 01, 2008

Accepted:Feb 01, 2009

How to Cite:Mohsen KhaliliMehrdad RoghaniMajid EkhlasiThe Effect of Aqueous Crocus sativus L. Extract on Intracerebroventricular Streptozotocin-induced Cognitive Deficits in Rat: a Behavioral Analysis.Iran J Pharm Res.8(3):e128636.https://doi.org/10.22037/ijpr.2010.809.

Abstract

Intracerebroventricular (ICV) injection of streptozotocin (STZ) causes cognitive impairment in rats. The beneficial effect of Crocus sativus L. extract (CSE) was evaluated on ICV STZ-induced learning, memory, and cognitive impairment in male rats. For this purpose, rats were injected with ICV STZ bilaterally, on days 1 and 3 (3 mg/kg). The STZ-injected rats received CSE (60 mg/kg; i.p.) every other day, starting one day before surgery, for three weeks. The learning and memory performance was assessed using passive avoidance paradigm, and for spatial cognition evaluation, Y-maze task was used. It was found that CSE-treated STZ-injected rats show higher correct choices and lower errors in Y maze than vehicle-treated STZ-injected rats. In addition, CSE administration significantly attenuated learning and memory impairment in treated STZ-injected group in passive avoidance test. Therefore, these results demonstrate the effectiveness of CSE in preventing the cognitive deficits caused by ICV STZ in rats and its potential in the treatment of neurodegenerative diseases such as Alzheimer’s disease (AD).

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Author(s):

Mohsen Khalili:[PubMed][Scholar]
Mehrdad Roghani:[PubMed][Scholar]
Majid Ekhlasi:[PubMed][Scholar]