Antihypertensive effects of some new nitroxyalkyl 1,4-dihydropyridine derivatives in rat model of two-kidney, one-clip hypertension

authors:

avatar Ali Akbar Nekooeian 1 , avatar Azadeh Khalili 1 , avatar Katayoun Javidnia 2 , 3 , avatar Ahmad Reza Mehdipour 2 , avatar Ramin Miri 2 , 3 , *

Department of Pharmacology, Faculty of Medicine, Shiraz University of Medical Science, Shiraz, Iran
Medicinal & Natural Products Chemistry Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Medicinal Chemistry, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
Iranian Journal of Pharmaceutical Research: Vol.8, issue 3; 193-199
published online: November 20, 2010
article type: Research Article
received: October 01, 2008
accepted: February 01, 2009
DOI: https://doi.org/10.22037/ijpr.2010.810

how to cite: Nekooeian A A, Khalili A, Javidnia K, Mehdipour A R, Miri R. Antihypertensive effects of some new nitroxyalkyl 1,4-dihydropyridine derivatives in rat model of two-kidney, one-clip hypertension. Iran J Pharm Res. 2009;8(3):e128637. https://doi.org/10.22037/ijpr.2010.810.

Abstract

Dihydropyridine calcium channel blockers consist one of the widely-used groups of drugs for the management of hypertension. In this study, antihypertensive effects of 5 newly synthesized derivatives of DHP was examined the in rat model of two-kidney, one-clip renal hypertension. The results showed that those compounds containing two nitroxy groups had less decreasing effect on MAP (Men Arterial Pressure) compared to those having one nitroxy group in 5 position. On the other hand, conformational analysis indicated that in two compounds with two chains (A and E), a great steric hindrance existed; therefore, steric hindrance is the most important factor for interaction of compounds with their receptors.