Anti-nociceptive Activity of Aqueous-methanolic Extract of Phytolacca americana Growing in Iran

authors:

avatar Mohammad Karami 1 , avatar Soodabeh Saeidnia 2 , avatar Naghi Shahabi Majd 3 , avatar Mohammad Ali Ebrahimzadeh ORCID 1 , * , avatar Neda Omrani 1 , avatar Asieh Salarian 4

Pharmaceutical Sciences Research Center and School of Pharmacy, Medical Sciences University of Mazandaran, Sari, Iran
Medical Plants Research Center, Tehran University of Medical Sciences, Tehran, Iran
Physiology and Pharmacology Department, School of Medicine, Medical Sciences University of Mazandaran, Sari, Iran
Resalat Health Center, Medical Sciences University of Mazandaran, Sari, Iran
Iranian Journal of Pharmaceutical Research: Vol.8, issue 3; 223-226
published online: November 20, 2010
article type: Rapid Communication
received: July 01, 2008
accepted: November 01, 2008
DOI: https://doi.org/10.22037/ijpr.2010.814

how to cite: Karami M, Saeidnia S, Shahabi Majd N, Ebrahimzadeh M A, Omrani N, et al. Anti-nociceptive Activity of Aqueous-methanolic Extract of Phytolacca americana Growing in Iran. Iran J Pharm Res. 2009;8(3):e128641. https://doi.org/10.22037/ijpr.2010.814.

Abstract

Abstract Anti-nociceptive activity of aerial parts of Phytolacca americana were investigated, using the hot plate method in mice. Results of the present study showed that the aqueous methanolic extract of aerial parts of P. americana produced a statistically significant increase in pain threshold after 30 min, in comparison with the control, at adose of 190 mg kg-1 (P<0.001). The activity was comparable to that of morphine (30 mg kg-1 i.p., p> 0.05). The anti-nociceptive activity of P. americana increased until the 60th min (P<0.05 compared to morphine). The results of this study support the extensive use of P. americana in Western Asia and America. The LD50 of extract following a 14 days acute toxicity study was calculated to be 208 mg kg-1 i.p.