Abstract
In the present work, the antinociceptive action was assayed in several experimental models in mice: writhing, formalin and hot plate tests. The crude alkaloid fraction (25, 50, 100 mg/kg) and in a dose-dependent manner significantly reduced the nociception by acetic acid intraperitoneal injection (P < 0.001). In the formalin test, the extract (50 and 100 mg/kg) also significantly reduced the painful stimulus in both phases of the test (P<0.001). Treatment with the extract (25, 50, 100 mg/kg) when given i.p. or pentazocine (5 mg/kg, s.c.) produced a significant increase of the reaction time in hot plate test. These result showed that the alkaloid extract of Solanum trilobatum contains active analgesic principles acting both centrally and peripherally.
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Copyright
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