Evaluation of In Vitro Cytotoxic Effects of Juniperus foetidissima andJuniperus sabina Extracts Against a Panel of Cancer Cells

Hojjat Sadeghi-aliabadi; Ahmad Emami; Morteza Saidi; Babak Sadeghi; Abbas Jafarian

doi:10.22037/ijpr.2010.823

IJ Pharmaceutical Research

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https://doi.org/10.22037/ijpr.2010.823

Evaluation of In Vitro Cytotoxic Effects of Juniperus foetidissima andJuniperus sabina Extracts Against a Panel of Cancer Cells

Author(s):

Hojjat Sadeghi-aliabadi^{1, 2,*},

Ahmad Emami³,

Morteza Saidi¹,

Babak Sadeghi¹,

Abbas Jafarian²

1Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

2Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

3Department of Pharmacognosy, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

IJ Pharmaceutical Research:Vol. 8, issue 4; 281-286

Published online:Nov 20, 2010

Article type:Research Article

Received:Nov 01, 2008

Accepted:Jan 01, 2009

How to Cite:Hojjat Sadeghi-aliabadiAhmad EmamiMorteza SaidiBabak SadeghiAbbas JafarianEvaluation of In Vitro Cytotoxic Effects of Juniperus foetidissima andJuniperus sabina Extracts Against a Panel of Cancer Cells.Iran J Pharm Res.8(4):e128650.https://doi.org/10.22037/ijpr.2010.823.

Abstract

Isolation of some potent anti-tumor compounds from medicinal plants has motivated researchers to screen different parts of plant for their anti-tumor effects. It has been reported that several species of conifers posses’ cytotoxic activities on some tumor cell lines. Here branchlets and berries of Juniperus foetidissima and J. sabina were collected, dried and ethanol extracts of them obtained using percolation. Extracts were dried in reduced pressure and cytotoxic effects of different concentrations (5, 10, 20 µg/ml) were evaluated by MTT assay against three tumor cell lines (Hela, KB, MDA-MB-468), using ELISA at 540 nm. The extracts of the branchlets of male and female of J.foetidissima and berries extract of J. sabina showed inhibitory activities against KB cells. Extracts of male branchlets of J. foetidissima and berries extract of J. sabina were cytotoxic (cell survival less than 50%) against Hela cell line. Regarding to MDA-MB-468, only the extract of male branchlets of J. foetidissima was cytotoxic. Extracts of J. sabina were not cytotoxic at tested concentrations. According to the results obtained by MTT assay, KB cells seem to be much more sensitive than the other cell lines.

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Author(s):

Hojjat Sadeghi-aliabadi:[PubMed][Scholar]
Ahmad Emami:[PubMed][Scholar]
Morteza Saidi:[PubMed][Scholar]
Babak Sadeghi:[PubMed][Scholar]
Abbas Jafarian:[PubMed][Scholar]