Immunomodulatory Activity of Aqueous Extract ofHeracleum persicum Desf. in Mice

Fariba Sharififar; Shirin Pournourmohammadi; Moslem Arabnejad; Ramin Rastegarianzadeh; Omid Ranjbaran; Amin Purhemmaty

doi:10.22037/ijpr.2010.824

IJ Pharmaceutical Research

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https://doi.org/10.22037/ijpr.2010.824

Immunomodulatory Activity of Aqueous Extract ofHeracleum persicum Desf. in Mice

Author(s):

Fariba Sharififar^1,*,

Shirin Pournourmohammadi²,

Moslem Arabnejad¹,

Ramin Rastegarianzadeh¹,

Omid Ranjbaran¹,

Amin Purhemmaty³

1Kerman University of Medical Sciences, Pharmaceutics Research Center, Department of Pharmacognosy, School of Pharmacy, Kerman, Iran

2Kerman University of Medical Sciences, Department of Toxicology-Pharmacology, School of Pharmacy, Kerman, Iran

3Bahonar University, Department of Botany, Kerman, Iran

IJ Pharmaceutical Research:Vol. 8, issue 4; 287-292

Published online:Nov 20, 2010

Article type:Research Article

Received:Aug 01, 2008

Accepted:Jun 01, 2009

How to Cite:Fariba SharififarShirin PournourmohammadiMoslem ArabnejadRamin RastegarianzadehOmid RanjbaranAmin Purhemmatyet al.Immunomodulatory Activity of Aqueous Extract ofHeracleum persicum Desf. in Mice.Iran J Pharm Res.8(4):e128651.https://doi.org/10.22037/ijpr.2010.824.

Abstract

Studies have demonstrated that plant extracts possess various biological characteristics, including immunomodulatory activity. Heracleum persicum Desf. (Apiaceae), a medicinal plant native to Iran, was studied for its immunomodulatory activity. Immunomodulatory activity of different doses of an aqueous extract of H. persicum, was evaluated in female Swiss albino mice. Mice were treated with three doses (50, 100 and 200 mg/kg body weight) for 5 days. Body weight, relative organ weight, delayed type hypersensitivity (DTH) response and haemagglutination titre (HT) were studied in various groups of animals. No significant body weight gain differences were recorded in various groups of animals. The results obtained show a significant increase (P < 0.05) in relative organ weight of spleen and liver, at doses of 50 and 100 mg/kg. No elevation in the levels of liver function test (LFT) enzymes and kidney relative weight was observed with the plant doses examined. The H. persicum extract elicited a significant increase (P < 0.05) in the DTH response at doses of 100 and 200 mg/kg. In the HT test, the plant extract showed a stimulatory effect at all doses, however these changes were significant at doses of 50 and 100 mg/kg. No mortality occurred with the tested doses. Overall, H. persicum showed a stimulatory effect on both humoral and cellular immune functions in mice.

Keywords

Toxicity

Haemagglutination titre

Delayed type hypersensitivity

Immunomodulation

Heracleum persicum

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Author(s):

Fariba Sharififar:[PubMed][Scholar]
Shirin Pournourmohammadi:[PubMed][Scholar]
Moslem Arabnejad:[PubMed][Scholar]
Ramin Rastegarianzadeh:[PubMed][Scholar]
Omid Ranjbaran:[PubMed][Scholar]
Amin Purhemmaty:[PubMed][Scholar]