Lipid Lowering Effect of Ethanolic Extract of Aerial Partsof Peucedanum pastinacifolium Boiss. and Hausskn.in Hypercholesterolemic Rats

Ahmad Movahedian; S.Ebrahim Sajjadi; Mahdi Ahmadi

doi:10.22037/ijpr.2010.826

IJ Pharmaceutical Research

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https://doi.org/10.22037/ijpr.2010.826

Lipid Lowering Effect of Ethanolic Extract of Aerial Partsof Peucedanum pastinacifolium Boiss. and Hausskn.in Hypercholesterolemic Rats

Author(s):

Ahmad Movahedian^1,*,

S.Ebrahim Sajjadi²,

Mahdi Ahmadi²

1Department of Clinical Biochemistry, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

2Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

IJ Pharmaceutical Research:Vol. 8, issue 4; 301-306

Published online:Nov 20, 2010

Article type:Research Article

Received:Aug 01, 2008

Accepted:Jan 01, 2009

How to Cite:Ahmad MovahedianS.Ebrahim SajjadiMahdi AhmadiLipid Lowering Effect of Ethanolic Extract of Aerial Partsof Peucedanum pastinacifolium Boiss. and Hausskn.in Hypercholesterolemic Rats.Iran J Pharm Res.8(4):e128653.https://doi.org/10.22037/ijpr.2010.826.

Abstract

Increased plasma cholesterol is known to be a major risk related to the development of coronary artery disease. The main purpose of this study was to determine possible effects of the ethanolic extract of aerial parts of Peucedanum pastinacifolium on the serum lipids in hypercholesterolemic rats. Experimental hypercholesterolemia was induced by feeding rats a cholesterol-enriched diet for 56 days. Hypercholesterolemic rats were classified into five groups. One group did not receive treatments and served as a control hypercholesterolemic group. The other four groups were fed the cholesterol-enriched diet in conjunction with 125, 250, 500 mg extract per kg of the body weight along with 20 mg atrovaststin per kg body weight, in a daily oral dose. A normal group of rats fed with a plain chow diet was also included in the study. After oral administration for 8 weeks, P. pastinacifolium extract produced significant decrease on serum total cholesterol, low-density lipoprotein cholesterol, triglyceride levels and atherogenic indices in hypercholesterolemic groups (P < 0.05). P. pastinacifolium extract had no effects on serum high-density lipoprotein cholesterol levels in these groups. It is concluded that the extract of aerial parts of P. pastinacifolium exhibits lipid lowering activity in hypercholesterolemic rats. However, further investigation would be necessary to evaluate the mechanism of action of the extract.

Keywords

Cholesterol

Peucedanum pastinacifolium

Lipoproteins

Hypercholesterolemia

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Author(s):

Ahmad Movahedian:[PubMed][Scholar]
S.Ebrahim Sajjadi:[PubMed][Scholar]
Mahdi Ahmadi:[PubMed][Scholar]