The Relationship between Serum Hemoglobin and Creatinine Levels and Intra-Hospital Mortality and Morbidity in Acute Myocardial Infarction

Afsoon Fazlinezhad; Maryam Hami; Mohammad Taghi Shakeri; Hoda Khatibi-Moghaddam; Maliheh Dadgarmoghadam; Majid Khadem-Rezaiyan; Sara Saffar Soflaei

doi:10.17795/icrj-9(4)220

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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https://doi.org/10.17795/icrj-9(4)220

The Relationship between Serum Hemoglobin and Creatinine Levels and Intra-Hospital Mortality and Morbidity in Acute Myocardial Infarction

Author(s):

Afsoon Fazlinezhad¹,

Maryam Hami²,

Mohammad Taghi Shakeri³,

Hoda Khatibi-Moghaddam⁴,

Maliheh Dadgarmoghadam³,

Majid Khadem-Rezaiyan⁴,

Sara Saffar Soflaei^5,*

1Cardiovascular Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2Department of Nephrology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3Department of Community Medicine and Public Health, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

4Student Research Committee, Department of Psychiatry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

5Student Research Committee, Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

International Cardiovascular Research Journal:Vol. 9, issue 4; e10912

Published online:Dec 31, 2015

Article type:Research Article

Received:Oct 23, 2014

Accepted:Apr 08, 2015

How to Cite:Afsoon FazlinezhadMaryam HamiMohammad Taghi ShakeriHoda Khatibi-MoghaddamMaliheh DadgarmoghadamMajid Khadem-RezaiyanSara Saffar Soflaeiet al.The Relationship between Serum Hemoglobin and Creatinine Levels and Intra-Hospital Mortality and Morbidity in Acute Myocardial Infarction.Int Cardiovasc Res J.9(4):e10912.https://doi.org/10.17795/icrj-9(4)220.

Abstract

Background: Studies have shown that Glomerular Filtration Rate (GFR) and Hemoglobin (Hb) concentrations are two predictive values for ST-elevation Myocardial Infarction (MI) mortality.
Objectives: This study aimed to investigate the relationship between GFR and Hb concentrations and intra-hospital mortality and electrocardiographic (ECG) and echocardiographic abnormalities in ST-elevation MI patients admitted to a highly equipped hospital in Mashhad. The results will help define some factors to manage these patients more efficiently.
Patients and Methods: This descriptive study aimed to assess the relationship between Hb and GFR concentrations and mortality and morbidity among 294 randomly selected patients with ST-elevation MI. Echocardiography, ECG, and routine laboratory tests, including Hb and creatinine, were performed for all the patients. Then, the data were entered into the SPSS statistical software, version 16 and were analyzed using chi-square, t-test, and ANOVA. P < 0.05 was considered as statistically significant.
Results: Intra-hospital mortality rate was 10.5%. Besides, the results showed higher levels of serum blood sugar (P < 0.001), higher levels of creatinine (P < 0.001), lower levels of GFR (P < 0.001), lower ejection fraction (P < 0.001), higher grades of left ventricular diastolic dysfunction (P = 0.002), and lower mean Hb concentration (P = 0.022) in the dead compared to the alive cases. Besides, the patients with mechanical complications had lower Hb levels (P = 0.008). The results showed no significant relationship between creatinine level and mechanical and electrical complications (P = 0.430 and P = 0.095, respectively). However, ejection fraction was significantly associated with GFR (P = 0.016).
Conclusions: According to the results, low levels of Hb and GFR could predict mortality caused by ST-elevation MI and ECG abnormalities could notify intra-hospital death. Moreover, lower Hb levels were associated with mechanical complications and could be used as a parameter for diagnosis of high-risk patients.

Keywords

Hemoglobins

Creatinine

Glomerular Filtration Rate

Myocardial Infarction

Mortality

Morbidity

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Author(s):

Afsoon Fazlinezhad:[PubMed][Scholar]
Maryam Hami:[PubMed][Scholar]
Mohammad Taghi Shakeri:[PubMed][Scholar]
Hoda Khatibi-Moghaddam:[PubMed][Scholar]
Maliheh Dadgarmoghadam:[PubMed][Scholar]
Majid Khadem-Rezaiyan:[PubMed][Scholar]
Sara Saffar Soflaei:[PubMed][Scholar]