Different Apolipoprotein E Polymorphisms Are Not Associated with Different Carotid Intima-Media Thickness Values in a Sample of Spanish General Population

Pilar  Calmarza; Jos&eacute;  Mar&iacute;a Trejo; Carlos  Lapresta; Mar&iacute;a  Fern&aacute;ndez; Pilar  L&oacute;pez

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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Different Apolipoprotein E Polymorphisms Are Not Associated with Different Carotid Intima-Media Thickness Values in a Sample of Spanish General Population

Authors:

Pilar Calmarza^1,*,

José María Trejo²,

Carlos Lapresta¹,

María Fernández³,

Pilar López²

1Hospital Universitario Miguel Servet, Zaragoza, Spain

2Complejo Asistencial, Burgos, Spain

3Hospital Santiago Apóstol, Miranda de Ebro, Burgos, Spain

International Cardiovascular Research Journal:Vol. 9, issue 2; e11399

Published online:Jun 30, 2015

Article type:Research Article

Received:Mar 12, 2017

Accepted:Jan 12, 2015

How to Cite:Pilar Calmarza José María TrejoCarlos LaprestaMaría FernándezPilar LópezDifferent Apolipoprotein E Polymorphisms Are Not Associated with Different Carotid Intima-Media Thickness Values in a Sample of Spanish General Population.9(2):e11399.

Abstract

Background: Apolipoprotein E (Apo E) is a key factor in the atherosclerosis process, but the influence of its genetic polimorphisms in southern Europe populations is not well known.

Objectives: The present transversal, population-based study aimed to determine if Apo E genetic polymorphism is associated with early atherosclerosis, as assessed by carotid Intima-Media Thickness (cIMT), or with presence of carotid atherosclerotic plaques.

Patients and Methods: The study sample included 171 individuals older than 40 years who were randomly selected from the population assigned to a district medical center of Burgos, Spain. The proportion of males and females in the sample and their ages matched the adult Spanish general population. cIMT and number of carotid atherosclerotic plaques were determined to assess if higher values were associated with a particular ApoE genetic polymorphism.

Results: Neither cIMT nor the number of atherosclerotic plaques differed among the subjects with Apo E2, E3, and E4 genotypes. However, both total cholesterol and Low Density Lipoprotein (LDL)-cholesterol were higher in the E4 than in the E2 group.

Conclusions: In this sample of adult Spanish population, no association was found between Apo E genotypes and cIMT.

Keywords

Apolipoprotein E

Carotid Intima-Media Thickness

Plaque

Atherosclerotic

Cardiovascular Diseases

Carotid Arteries

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