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Prevalence of Hypovitaminosis D in Patients with Coronary Artery Disease and the Correlation of vitamin D level with High Sensitive C-reactive Protein, A Report from Southern Iran

AUTHORS

avatar Laleh Mahmoudi 1 , avatar Sara Asadi 1 , avatar Alireza Moaref ORCID 2 , avatar Omid Moradi ORCID 3 , avatar Peyman Izadpanah 2 , *

1 Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IR Iran

2 Cardiovascular Research Center, Shiraz University of Medial Sciences, Shiraz, IR Iran

3 Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

How to Cite: Mahmoudi L, Asadi S, Moaref A, Moradi O, Izadpanah P. Prevalence of Hypovitaminosis D in Patients with Coronary Artery Disease and the Correlation of vitamin D level with High Sensitive C-reactive Protein, A Report from Southern Iran. Int Cardio Res J. 2021;15(3):e119230.

ARTICLE INFORMATION

International Cardiovascular Research Journal: 15 (3); e119230
Published Online: September 30, 2021
Article Type: Brief Report
Received: August 31, 2021
Revised: September 23, 2021
Accepted: October 06, 2021
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Abstract

Background: Coronary Artery Disease (CAD) is the leading non-infectious cause of
mortality in Iran. Inflammation plays an important role in CAD. Additionally, vitamin
D deficiency is linked to a higher risk of cardiovascular mortality.
Objectives: This study aimed to evaluate the prevalence of hypovitaminosis D in patients
with CAD and to determine the level of high-sensitivity C-Reactive Protein (hs-CRP) as
the main inflammatory marker.
Methods: In this cross-sectional study, the prevalence of hypovitaminosis D was assessed
in patients with CAD during 14 months. The study was approved by the Ethics Committee
of Shiraz University of Medical Sciences. The patients were evaluated regarding the level
of 25-OH cholecalciferol via high-performance liquid chromatography and hs-CRP level
via enzyme linked immunosorbent assay. The related demographics, medical history,
and lipid profile were evaluated, as well. Insufficient and deficient levels of 25-OH
vitamin D were defined as < 30 ng/mL and < 12 ng/mL, respectively. The patients with
insufficient vitamin D levels were evaluated regarding the hs-CRP level, as the cardiac
inflammatory marker. The correlation between vitamin D level and hs-CRP was also
determined using a bivariate method reporting Pearson’s correlation coefficient in the
SPSS software (IBM Corp., version 25).
Results: In this study, hypovitaminosis D was reported in 257 (65.1%) out of the 395
patients with CAD. The mean age of the patients was 62.54 ± 8.81 years, and 77 ones
(55.0%) were female. Vitamin D deficiency was more prevalent in the patients with
hs-CRP levels > 3 mg/L (P = 0.003). In addition, a significant negative correlation was
observed between vitamin D serum level and hs-CRP (R = -0.601, P < 0.001).
Conclusions: Vitamin D deficiency was prevalent in the patients with CAD, and
decreased vitamin D levels were associated with increased hs-CRP levels. Hence, CAD
patients should be evaluated regarding the vitamin D status.

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References

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© 2021, Shiraz University of Medical Sciences.
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