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Causative Microorganisms in Infective Endocarditis: Prospective Data from the Iranian Registry of Infective Endocarditis (IRIE)

AUTHORS

avatar Pardis Moradnejad ORCID 1 , avatar Behshid Ghadrdoost ORCID 1 , avatar Anita Sadeghpour ORCID 2 , avatar Majid Maleki ORCID 2 , avatar Hamidreza Pasha ORCID 1 , avatar Monireh Kamali ORCID 1 , avatar Shirin Manshouri ORCID 1 , avatar Ata Firouzi ORCID 3 , avatar Sara Lotfian ORCID 1 , avatar Azadeh Afzalnia ORCID 1 , avatar Zahra Shafii ORCID 1 , avatar Nasim Naderi ORCID 1 , avatar Neda Alijani ORCID 4 , avatar Mahshid Hesami ORCID 1 , avatar Shabnam Boudagh ORCID 2 , *

1 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran

2 Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran

3 Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran

4 Department of Infectious Disease, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IR Iran

How to Cite: Moradnejad P, Ghadrdoost B, Sadeghpour A, Maleki M , Pasha H, et al. Causative Microorganisms in Infective Endocarditis: Prospective Data from the Iranian Registry of Infective Endocarditis (IRIE). Int Cardio Res J. 2022;16(2):e121998.

ARTICLE INFORMATION

International Cardiovascular Research Journal: 16 (2); 55-60
Published Online: June 15, 2022
Article Type: Research Article
Received: December 15, 2021
Accepted: February 22, 2022
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Abstract

Background: Infective Endocarditis (IE) is a life-threatening disease. Regardless
of improved healthcare, the incidence of IE has increased over time. A variety of
microorganisms have been found to be associated with IE.
Objectives: This study aimed to determine the incidence of various microorganisms in
patients admitted with IE and to assess their relationships with in-hospital complications.
Methods: This prospective cross-sectional study was conducted on patients with definite
or possible IE based on the Duke criteria at a tertiary referral center between 2016 and
2021. Blood cultures were performed for all the patients to document the positive or
negative blood cultures as well as the types of microorganism. Statistical analyses were
performed using the SPSS 18 software.
Results: The study population consisted of 286 patients (181 males (63.3%) and 105 females
(36.7%)) with the mean age of 49.67 ± 17.11 years. The most common cardiac predisposing
factor was the prosthetic valve (n = 110, 38.5%) followed by a history of congenital heart
disease (n = 68, 23.8%), while the most frequent non-cardiac predisposing factors were
a history of chronic kidney disease (n = 75, 26.2%) and diabetes mellitus (n = 53, 18.5%).
The most frequent causative microorganisms were coagulase-negative Staphylococcus (n
= 37, 12.9%), Staphylococcus aureus (n = 31, 10.4%), Enterococcus (n = 29, 10.1%), and
Streptococcus viridans (n = 14, 4.9%). The most common complications were acute renal
failure (26.6%), heart failure (17.5%), and pulmonary involvement (8.4%).
Conclusions: The frequencies of microorganisms related to IE, especially culturenegative
IE, vary in different countries, precluding the practical use of a specific
guideline around the world. Further research is, therefore, required to determine the
epidemiology and microbiology of IE in different countries with a view to eventually
devising an individualized guideline appropriate to the epidemiology and microbiology
of IE in every country.

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References

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© 2022, Shiraz University of Medical Sciences.
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