The Relationship between QT Interval Dispersion and End-Stage Liver Disease Score in the Patients Undergoing Orthotopic Liver Transplantation

Moghgan  Zahmatkeshan; Ebrahim  Fallahzadeh; Seyedeh  Sadat Najib; Hamid  Amoozgar; Seyed Ali  Malekhosseini; Saman  Nikeghbalian

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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The Relationship between QT Interval Dispersion and End-Stage Liver Disease Score in the Patients Undergoing Orthotopic Liver Transplantation

Author(s):

Moghgan Zahmatkeshan¹,

Ebrahim Fallahzadeh²,

Seyedeh Sadat Najib³,

Hamid Amoozgar^4,*,

Seyed Ali Malekhosseini¹,

Saman Nikeghbalian¹

1Transplant Research Center, Shiraz, Iran

2Department of Internal medicine, Shiraz University of Medical Sciences, Shiraz, Iran

3Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran

4Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

International Cardiovascular Research Journal:Vol. 7, issue 4; e12369

Published online:Dec 31, 2013

Article type:Research Article

Received:May 01, 2017

Accepted:Nov 09, 2013

How to Cite:Moghgan ZahmatkeshanEbrahim FallahzadehSeyedeh Sadat NajibHamid AmoozgarSeyed Ali MalekhosseiniSaman Nikeghbalianet al.The Relationship between QT Interval Dispersion and End-Stage Liver Disease Score in the Patients Undergoing Orthotopic Liver Transplantation.Int Cardiovasc Res J.7(4):e12369.

Abstract

Background:: This study was performed to determine the changes in corrected QT (QTc) and QT dispersion and their relationship with end-stage liver disease score in the children undergoing orthotopic liver transplantation.

Methods:: This case-control study was performed in a 2–year period from February 2009 to March 2011 in Department of Organ Transplantation of Nemazee Hospital. We consecutively included all the 22 pediatric patients undergoing orthotopic liver transplantation and 22 healthy age- and sex-matched controls. Electrocardiogram (ECG) was performed for all the patients and controls before and 6 months after the transplantation and the QTc was calculated according to Bazett’s formula in lead I, aVF, andV1. Besides, QT dispersion was calculated by the difference between maximum and minimum QTc in the three leads. The data were statistically analyzed using independent sample t-test, chi-square test, paired t-test, and Pearson correlation analysis. In addition, P value < 0.05 was considered as statistically significant.

Results:: The patients with end-stage liver disease had significantly longer QTc dispersion (P = 0.002) compared to the controls. The post-transplantation QTc dispersion (P = 0.003) was also significantly longer compared to the healthy controls. Moreover, pretransplant QTc dispersion was negatively correlated with weight (r = ‒0.589, P = 0.004) and Child-Pugh score (r = ‒0.549, P = 0.008).

Conclusions:: The patients with ESLD awaiting liver transplantation suffer from prolonged QTc interval predisposing them to ventricular tachycardia. The QTc prolongation in these patients does not response to liver transplantation. This study revealed a fine negative correlation between the Child- Pugh score and QTc.

Keywords

Liver Transplantation

Electrocardiography

QT

Dispersion

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