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Urine β 2-Microglobolin in the Patients with Congenital Heart Disease

AUTHORS

avatar Noor Mohammad Noori 1 , avatar Simin Sadeghi 2 , avatar Iraj Shahramian 3 , * , avatar Kambiz Keshavarz 4

1 Pediatric Cardiology, Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

2 Pediatric Nephrology, Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

3 Department of Pediatrics, Children and Adolescent Health Research Center, Zabol University of Medical Sciences, Zabol, Iran

4 Department of Pediatrics, Yasuj University of Medical Sciences, Yasuj, Iran

How to Cite: Noori N M , Sadeghi S , Shahramian I, Keshavarz K . Urine β 2-Microglobolin in the Patients with Congenital Heart Disease. Int Cardio Res J. 2017;7(2):e12705.

ARTICLE INFORMATION

International Cardiovascular Research Journal: 7 (2); e12705
Published Online: June 30, 2013
Article Type: Research Article
Received: May 07, 2017
Accepted: May 03, 2013
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Abstract

Background: This study aimed to evaluate the renal tubular function in the patients with congenital heart disease using β2-microglobulin.
Methods: In this case-control study, based on oxymetry, the patients with congenital heart disease were divided into two groups of cyanotic (n=20) and acyanotic (n=20). Congenital heart disease was diagnosed by echocardiography. Healthy individuals within the same age and sex groups were used as controls. Na+, β2-micro globulin, creatinine (Cr), and β2-microglobulin/Cr ratio were measured in random urine samples and the results were compared to the same parameters in the control group using Tukey, One-Way ANOVA, and X2 tests.
Results: Based on the study results, urine sodium in the patients with cyanotic heart disease was significantly different from that of the controls (P=0.023). The results also revealed a significant difference between the two groups with congenital heart disease regarding urine β2-microglobulin (P=0.045).
In addition, the patients with cyanotic heart disease were significantly different from those with acyanotic heart disease and the controls regarding urine β2-micro globulin/Cr ratio (P=0.012 and P=0.026, respectively).
Conclusions: The results of this study demonstrated that renal tubular dysfunction began in the patients with congenital heart disease, especially in those with cyanotic congenital heart disease. Besides, early diagnosis before cardiac surgery leads to better control of renal tubular disease.

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References

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© 2017, Shiraz University of Medical Sciences.
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