Urine β 2-Microglobolin in the Patients with Congenital Heart Disease

Noor Mohammad  Noori; Simin  Sadeghi; Iraj Shahramian; Kambiz  Keshavarz

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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Urine β 2-Microglobolin in the Patients with Congenital Heart Disease

Author(s):

Noor Mohammad Noori¹,

Simin Sadeghi²,

Iraj Shahramian^3,*,

Kambiz Keshavarz⁴

1Pediatric Cardiology, Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

2Pediatric Nephrology, Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

3Department of Pediatrics, Children and Adolescent Health Research Center, Zabol University of Medical Sciences, Zabol, Iran

4Department of Pediatrics, Yasuj University of Medical Sciences, Yasuj, Iran

International Cardiovascular Research Journal:Vol. 7, issue 2; e12705

Published online:Jun 30, 2013

Article type:Research Article

Received:May 07, 2017

Accepted:May 03, 2013

How to Cite:Noor Mohammad NooriSimin SadeghiIraj ShahramianKambiz KeshavarzUrine β 2-Microglobolin in the Patients with Congenital Heart Disease.Int Cardiovasc Res J.2013;7(2):e12705.

Abstract

Background: This study aimed to evaluate the renal tubular function in the patients with congenital heart disease using β₂-microglobulin.

Methods: In this case-control study, based on oxymetry, the patients with congenital heart disease were divided into two groups of cyanotic (n=20) and acyanotic (n=20). Congenital heart disease was diagnosed by echocardiography. Healthy individuals within the same age and sex groups were used as controls. Na⁺, β₂-micro globulin, creatinine (Cr), and β₂-microglobulin/Cr ratio were measured in random urine samples and the results were compared to the same parameters in the control group using Tukey, One-Way ANOVA, and X² tests.

Results: Based on the study results, urine sodium in the patients with cyanotic heart disease was significantly different from that of the controls (P=0.023). The results also revealed a significant difference between the two groups with congenital heart disease regarding urine β₂-microglobulin (P=0.045).
In addition, the patients with cyanotic heart disease were significantly different from those with acyanotic heart disease and the controls regarding urine β₂-micro globulin/Cr ratio (P=0.012 and P=0.026, respectively).

Conclusions: The results of this study demonstrated that renal tubular dysfunction began in the patients with congenital heart disease, especially in those with cyanotic congenital heart disease. Besides, early diagnosis before cardiac surgery leads to better control of renal tubular disease.

Keywords

Congenital Heart Disease

Renal Function

Children

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