Improvement of Endothelium-Dependent Relaxation in Aorta of Rat Models Type 1 and 2 Diabetes by Hespiridin

A   Kouhpayeh; H  Mirkhani; Ali Akbar   Nekooeian

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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Improvement of Endothelium-Dependent Relaxation in Aorta of Rat Models Type 1 and 2 Diabetes by Hespiridin

Author(s):

A Kouhpayeh¹,

H Mirkhani^2,*,

Ali Akbar Nekooeian³

1Department of Pharmacology, Medical School, Iran

2Medicinal & Natural Products Chemistry Research Centre, Iran

3Cardiovascular Pharmacology Research Center, Department of Pharmacology, Shiraz University of Medical Sciences Shiraz, Iran

International Cardiovascular Research Journal:Vol. 1, issue 4; e69298

Published online:Dec 31, 2007

Article type:Research Article

Received:Apr 24, 2018

Accepted:Dec 31, 2007

How to Cite:A KouhpayehH MirkhaniAli Akbar NekooeianImprovement of Endothelium-Dependent Relaxation in Aorta of Rat Models Type 1 and 2 Diabetes by Hespiridin.Int Cardiovasc Res J.1(4):e69298.

Abstract

Background: Vascular disease is the principal cause of morbidity and mortality in patients with diabetes. A
considerable body of evidence implicates oxidative stress as an important pathogenic factor of diabetic vasculopathies.
In the present study, the effect of hesperidin, a flavanone glycoside with antioxidant activity, is studied
in endothelium-dependent relaxation of the rat aorta in experimental diabetes mellitus type 1 (DM1) and type 2
(DM2).
Patients and Methods: Single dose intraperitoneal injection of streptozocin (60mg/kg) and subcutaneous daily
injection of dexamethasone (10μg/kg for one month) were used to induce DM1 and DM2, respectively. Hesperidin
(500mg/kg) was administered orally for two months in DM1 and one month in DM2. The effect of acetylcholine
(Ach) on phenyl ephrine (PE) induced. PE contracted aorta was then studied and the EC50 and maximal
relaxant effect of Ach were calculated and compared in the two groups.
Results: In the experimental DM1, hesperidin restored endothelium-dependent relaxation near to those of normal
animals. Its effect on experimental DM2 consisted of a significant reduction of EC50 value of Ach compared
to those of diabetic animals. It also showed a great but non-significant effect (P=0.07) on Ach-induced maximum
relaxation compared to DM2 untreated animals.
Conclusion: These results show that hesperidin can improve vascular endothelial dysfunction in experimental
diabetes mellitus.

Keywords

Experimental Diabetes Mellitus

Endothelium

Hesperidin

Aorta

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