The Therapeutic Effect of Human Stem Cell Therapy on the Expanded Disability Status Scale Improvement in Multiple Sclerosis

Shahram Darabi; Ali Asghar Keramatinia; Aliye Roosta Tasouji; Somayeh Niknazar; Navid Ahmady Roozbahany; Leila Darabi; Hojjat-allah Abbaszadeh; Fariborz Rashnoo

doi:10.22037/jcma.v8i3.39986

Journal of Cellular & Molecular Anesthesia

Journal Information Editors & Boards Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement New Publisher Announcement Reviewer and AE Registration Form Contact Us Support

APC

Authors Guide Submit Manuscript

https://doi.org/10.22037/jcma.v8i3.39986

The Therapeutic Effect of Human Stem Cell Therapy on the Expanded Disability Status Scale Improvement in Multiple Sclerosis

Author(s):

Shahram Darabi^1,*,

Ali Asghar Keramatinia²,

Aliye Roosta Tasouji³,

Somayeh Niknazar⁴,

Navid Ahmady Roozbahany⁵,

Leila Darabi⁶,

Hojjat-allah Abbaszadeh

⁷,

Fariborz Rashnoo⁸

1Cellular and Molecular Research Center, Research Institute for Non Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran

2Laser Application in Medical Sciences Research Center and Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4Hearing Disorders Research Center, Loghman Hakim Hospital and Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran

5Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran and Private Practice, Bradford ON, Canada

6Department of Neurology, Amir Al-Momenin Hospital, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran

7Laser Application in Medical Sciences Research Center, Hearing Disorders Research Center, and Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

8Department of General Surgery, School of Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Journal of Cellular & Molecular Anesthesia:Vol. 8, issue 3; e149226

Published online:Feb 26, 2023

Article type:Review

How to Cite:Shahram DarabiAli Asghar KeramatiniaAliye Roosta TasoujiSomayeh NiknazarNavid Ahmady RoozbahanyLeila DarabiHojjat-allah AbbaszadehFariborz Rashnooet al.The Therapeutic Effect of Human Stem Cell Therapy on the Expanded Disability Status Scale Improvement in Multiple Sclerosis.J Cell Mol Anesth.8(3):e149226.https://doi.org/10.22037/jcma.v8i3.39986.

Abstract

Multiple Sclerosis (MS) is a central nervous system inflammatory disease in which the myelin sheaths of neurons are damaged. This impairs the ability of the neurons for signal conduction and communication and causes many neurological signs and symptoms. In this study, we evaluated stem cell therapy for multiple sclerosis. We reviewed the scientific literature focusing on stem cell therapy for multiple sclerosis available from 2003 to 2022. This narrative systematic review was performed to evaluate the effect of human stem cell therapy on expanded disability status scale (EDSS) improvement in multiple sclerosis. No time limits were set for the search and all relevant clinical trials were included. The results showed that the rate of recovery of patients with stem cell therapy depends on the rate of stem cell injection and the frequency, the volume of injected cells, and the rate of disease progression. Overall, the survival rate and quality of life increased following the treatment. The expanded disability status scale changed with stem cell injection, but this change was not significant. Most cases experienced an improvement in bladder control. Death or hospitalization after injection and severe allergies were not observed. Our results showed stem cells could increase the quality of life and survival and reduce the incidence of motor symptoms in MS patients.

Keywords

References

1.
References are in the PDF file of the article.

comments

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

CrossRef 0

Metrics

Get Permission (article level)

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Shahram Darabi:[PubMed][Scholar]
Ali Asghar Keramatinia:[PubMed][Scholar]
Aliye Roosta Tasouji:[PubMed][Scholar]
Somayeh Niknazar:[PubMed][Scholar]
Navid Ahmady Roozbahany:[PubMed][Scholar]
Leila Darabi:[PubMed][Scholar]
Hojjat-allah Abbaszadeh:[PubMed][Scholar]
Fariborz Rashnoo:[PubMed][Scholar]