0.05); at the same time, there was no statistically significant difference regarding the protective effects of volatile anesthetic gases on ischemic outcome (p value>0.05).Discussion: this study demonstrated that all volatile anesthetics could lead to attenuation of myocardial infarct size; though there is no difference between different doses of volatile agents regarding their protective effects and the protective effects of volatile anesthetics are not different regarding their the main genes involved in cardioprotectionKey words: volatile, ischemia reperfusion, ischemia reperfusion"/>