Effect of Ketofol instead of Propofol on hemodynamic stabilization for induction of Anesthesia in Laparatomy

Seyed Amir Mohajerani; alireza jahangirifard

doi:10.22037/jcma.v2i2.14203

Journal of Cellular & Molecular Anesthesia

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https://doi.org/10.22037/jcma.v2i2.14203

Effect of Ketofol instead of Propofol on hemodynamic stabilization for induction of Anesthesia in Laparatomy

Author(s):

Seyed Amir Mohajerani¹,

alireza jahangirifard²

1Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

Journal of Cellular & Molecular Anesthesia:Vol. 2, issue 2; e149527

Published online:May 12, 2017

Article type:Original Articles

How to Cite:Seyed Amir Mohajeranialireza jahangirifardEffect of Ketofol instead of Propofol on hemodynamic stabilization for induction of Anesthesia in Laparatomy.J Cell Mol Anesth.2(2):e149527.https://doi.org/10.22037/jcma.v2i2.14203.

Abstract

Introduction: Hemodynamic alterations are a common complication during anesthetic induction with intravenous anesthesia. Hypotension due to propofol injection may be very severe in cardiac vascular patient. Ketamine produces the significant increasing but temporary in systematic blood stream, heartbeat, cardiac output through central sympathetic stimulation.Objective: To determine effect of ketofol and propofol for induction of anesthesia on hemodynamic changes during induction of anesthesiaMethods: In a randomized cinical trial study 96 patient who were candidate for laparotomy enrolled and divided into two random group of propofol (48 person) and ketofol (48 person). Hemodynamic changes were recorded and examined after induction, after intubation and 5 and 10 minutes after intubation.Results: Heart rate was significantly variable in propofol group compare to ketofol group. Systolic, Diastolic, and mean arterial blood pressure was not significantly changed during time period of recording in ketofol group. However, blood pressure was significantly changed during the study in propofol group.Conclusion: ketofol is a proper alternative to propofol to stabilize heart rate and blood pressure in laparatomy.

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Author(s):

Seyed Amir Mohajerani:[PubMed][Scholar]
alireza jahangirifard:[PubMed][Scholar]