Does increased Nitric Oxide production and oxidative stress due to high fat diet affect cardiac function after myocardial infarction?

authors:

avatar marjan aghajani ORCID 1 , * , avatar Alireza Imani ORCID 2 , avatar Mahdieh Faghihi 3 , avatar Mohammad reza Vaez Mahdavi 4 , avatar Sarah Mahboubi 5 , avatar Fatemeh Moradi 3 , avatar Ehsan Kazemi-Moghaddam ORCID 6

1. Department of physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran 2. Department of Physiology, Medical Faculty, Shahed University, Tehran, Iran
1.Associate Professor, Physiology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 2. Occupational Sleep Research Center, Tehran University of Medical Sciences, Tehran, Iran
Department of physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
1. Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran 2. Department of Physiology, Medical Faculty, Shahed University, Tehran, Iran
Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
1. Shiraz Burn and Wound Healing Research center, Amir-al-momenin burn hospital, Shiraz University of Medical Sciences, Iran 2. Department of Microbiology, Medical Faculty, Shahed University, Tehran, Iran
Journal of Cellular & Molecular Anesthesia: Vol.2, issue 1; e149528
published online: January 01, 2017
article type: Original Articles
DOI: https://doi.org/10.22037/jcma.v2i1.14288

how to cite: aghajani M, Imani A, Faghihi M, Vaez Mahdavi M R, Mahboubi S, et al. Does increased Nitric Oxide production and oxidative stress due to high fat diet affect cardiac function after myocardial infarction?. J Cell Mol Anesth. 2017;2(1):e149528. https://doi.org/10.22037/jcma.v2i1.14288.

Abstract

Background &Objectives: High fat (HF) diet by affecting the oxidative stress and nitric oxide (NO) production may lead to different effects on function of the heart after myocardial infarction (MI). In the present study we aimed to address the hypothesis that high release of NO by activated macrophages affects LV function after MI.Methods: The animals were randomly divided into four groups comprising each of 10 rats: 1) Sham; 2) MI; 3) Sham+ HF diet; 4) MI+ HF diet. Animals fed with HF diet 30 days before sham and MI surgery. MI was induced by permanent ligation of left anterior descending coronary artery (LAD). Nitric oxide (NO) production of peritoneal macrophages, the concentrations of MDA in the heart and the infarct size were measured.Results: Our study indicated that HF has adverse effects on myocardium and it may increase NO production as well as oxidative stress, resulting in augmentation of infarct size.Conclusion: Our results add to our knowledge that HF diet was associated with overproduction of NO by peritoneal macrophages and ROS that lead to development of infarct size and adverse remodeling.

References

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    References are in the PDF file of the article.