Cellular and Molecular Mechanisms in Perioperative Hepatic Protection: A Review of Current Interventions

2MD, Associate Professor, Clinical Research Development Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Journal of Cellular & Molecular Anesthesia:Vol. 2, issue 2; e149530

Published online:Jun 30, 2017

Article type:Review

How to Cite:Talebi Z, Peyvandi H, Dabbagh A. Cellular and Molecular Mechanisms in Perioperative Hepatic Protection: A Review of Current Interventions. J Cell Mol Anesth. 2017;2(2):e149530. doi: https://doi.org/10.22037/jcma.v2i2.14839

Abstract

Liver is one of the most important organs needing great concern during the perioperative period. There are a number of different mechanisms that interact with liver cells and might affect their integrity and cell live. Though these mechanisms are not all the same, there is a great common point: all affect the metabolic pathways of the liver. Ischemia, anesthetic drug effects and other perioperative insults may affect the liver. Disturbance in an organ?s blood flow is an inherent part of diverse surgical procedures, which leads to lack of oxygen and nutrient supply. These ischemic periods can be particularly long in case of liver surgeries, such as resection of large hepatic tumors, management of hepatic trauma and liver transplant. Once the blood flow and oxygen supply are restored, the interruption of blood flow affects the oxygen dependent cells in liver, which require mitochondrial oxidative phosphorylation for their metabolism. Molecular mechanisms such as Redox status, ionic interchange disturbances as well as different mediators and cells like KC, SEC, dendritic cells, leukocytes, and lymphocytes, are involved in the process ultimately leading to cell death by apoptosis and necrosis. This review provides an overview on the cellular and molecular mechanisms involved in liver injuries, categorizing these mechanisms in 3 different classes: preoperative mechanisms, intraoperative mechanisms and postoperative mechanisms. Each of them are discussed in a different part of the manuscript

Keywords

Cellular and Molecular Mechanisms

Perioperative Hepatic Protection

Import into EndNote Import into BibTex

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 10
Last Update: 3 weeks ago
Scopus by Title: 10
Last Update: 3 weeks ago
Scopus by Title (Ref): 10
Last Update: 3 weeks ago
CrossRef: 0
Last Update: 1 day ago

Metrics

Get Permission (article level)

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Zahra Talebi:[PubMed][Scholar]
Hassan Peyvandi:[PubMed][Scholar]
Ali Dabbagh:[PubMed][Scholar]

Outlines

Cellular and Molecular Mechanisms in Perioperative Hepatic Protection: A Review of Current Interventions

Abstract

Crossmark

Checking

Last Update: 3 weeks ago

Last Update: 3 weeks ago

Last Update: 3 weeks ago

Last Update: 1 day ago