Crouzon Syndrome: a fibroblast growth factor receptor 2 gene mutation

authors:

avatar Farhad Safari ORCID 1 , * , avatar Kamran Mottaghi ORCID 1 , avatar Rofeideh Fallahinejadghajari 1 , avatar Masoud Nashibi ORCID 1

Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences
Journal of Cellular & Molecular Anesthesia: Vol.2, issue 1; e149531
article type: Brief Communications
DOI: https://doi.org/10.22037/jcma.v2i1.14905

how to cite: Safari F, Mottaghi K, Fallahinejadghajari R, Nashibi M. Crouzon Syndrome: a fibroblast growth factor receptor 2 gene mutation. J Cell Mol Anesth. 2017;2(1):e149531. https://doi.org/10.22037/jcma.v2i1.14905.

Abstract

Crouzon syndrome is a rare autosomal dominant premature cranyosynostosis, caused by fibroblast growth factor receptor 2 gene mutation on chromosome 10. The predominant skull and facial malformations with potential compromise airway make the crouzon syndrome a demanding issue for anesthesiologists and surgeons, required dynamic team work. In this report we describe a child, a known case of Crouzon syndrome who was a candidate for optic nerve decompression through endoscopic surgery. The anesthetic considerations and management are presented.Key words: Crouzon Syndrome, FGFR2 gene, Difficult Intubation, Anesthesia