Effect of Prophylactic Vasopressin on Hemodynamic Parameters after Coronary Artery Bypass Graft Surgery

1Assistant Professor of Anesthesiology, Fellowship in Cardiac Anesthesia, Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) ,ShahidBeheshti University of Medical Science, Tehran, Iran

2post speciality in criticalcare, Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) ,ShahidBeheshti University of Medical Science, Tehran, Iran

3Assistant professor of Anesthesiology, Anesthesiology Research Center , ShahidBeheshti University of Medical Science, Tehran, Iran

4Assistant of Anesthesiology,ShahidBeheshti University of Medical Science, Tehran, Iran

5Anesthesiologist, Department of Anesthesiology, lorestanan University of Medical Sciences, Khoram Abad, Iran

6Assistant Professor of Cardiac Surgery,Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), ShahidBeheshti University of Medical Sciences, Tehran, Iran

7Assistant Professor of Anesthesiology, Fellowship in Cardiac Anesthesia,KermanUniversity of Medical Sciences, Kerman, Iran

Journal of Cellular & Molecular Anesthesia:Vol. 2, issue 3; e149535

Published online:Aug 07, 2017

Article type:Original Articles

How to Cite:jahangirifard A, Golestani Eraghi M, Fani K, Tafrishinejad A, Dadashpour N, et al. Effect of Prophylactic Vasopressin on Hemodynamic Parameters after Coronary Artery Bypass Graft Surgery.J Cell Mol Anesth.2017;2(3):e149535.https://doi.org/10.22037/jcma.v2i3.15315.

Abstract

Background: As common complications of Coronary artery bypass grafting (CABG), low vascular resistance and hypotension could be life threatening . The aim of present study was to investigate the effect of low-dose vasopressin on hemodynamics in CABG patients.Material &Methods: In this randomized double-blinded clinical trial, 80 patients undergoing selective CABG were randomly divided into two equal case and control groups (n=40). Case group was received vasopressin 0.03 IU/min 30 minute before the end of cardio-pulmonary bypass (CPB) until one hour after that. Control group was received normal saline in the same manner. Dopamine?requirement, ICU stay, heart rate (HR), mean arterial blood pressure (MAP), central venues pressure (CVP) and atrial blood acidity (PH) were recorded and compared between groups ?in 5 phases ( 0,30,60,90,120 min) after separation of CPB.Results: There was no significant difference between two groups in number of patients with severe hypotension (11 vs. 12 patients in case and control group respectively). CVP was corrected and then dopamine administration was compared in both group. In vasopressin and placebo group, 3 vs 11 patients need to dopamine administration immediately after separation from CPB (p= 0.018) and 4 vs 12 patients later in ICU (p=0.024) respectively. The mean needed dose of dopamine in vasopressin and placebo group immediately after separation from CPB were 7.63?3.42 vs 9.21?2.08 ?g/kg/min (p=0.031) and later in ICU were 7.42?2.02 vs 8.66?4.08 ?g/kg/min (p=0.045) respectively, which was significantly lower in vasopressin group in comparison with placebo group.Conclusion: Based on our results low-dose vasopressin administration significantly reduced the mean needed dose of required dopamine, 24 hours urinary output, Duration of mechanical ventilation and patient?s heart rate.

Keywords

vasopressin

hemodynamic parameters

CABG

References

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References are in the PDF file of the article.

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Author(s):

alireza jahangirifard:[PubMed][Scholar]
Majid Golestani Eraghi:[PubMed][Scholar]
Kamal Fani:[PubMed][Scholar]
Arash Tafrishinejad:[PubMed][Scholar]
Niloufar Dadashpour:[PubMed][Scholar]
Zargham Hossein Ahmadi:[PubMed][Scholar]
shirin salagegheh:[PubMed][Scholar]